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2008
Gratze, P., Dechend, R., Stocker, C., Park, J.-K., Feldt, S., Shagdarsuren, E.,
Wellner, M., Gueler, F., Rong, S., Gross, V., Obst, M., Plehm, R., Alenina, N., Zenclussen, A., Titze, J.,
Small, K., Yokota, Y., Zenke, M., Luft, F.C. and Muller, D.N.:
Novel role for inhibitor of differentiation Id2 in the genesis of Ang II-induced hypertension.
Circulation, 117: 2645-2656, 2008.

Uematsu, S., Fujimoto, K., Yang, B.-G., Ishii, K.J., Yokota, Y., Kiyono, H., Miyasaka, M., Jang, M.H. and Akira, S.:
Regulation of gut immunity by TLR5+ lamina propria dendritic cells.
Nat. Immunol., 9: 769-776, 2008.

Ji, M., Li, H., Suh, H.S., Klarmann, K.D., Yokota, Y. Keller, J.R.:
Id2 Intrinsically Regulates Lymphoid and erythroid development via interaction with different target proteins.
Blood in press.

Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M.,
Mastuo, K., Penninger, J.M., Takayanagi, H., Yokota, Y., Yamada, H., Yoshikai, Y., Inoue, J., Akiyama, T. and Takahama, Y. :
RANKL produced by positively selected thymocytes fosters medullary thymicepithelial cells that express autoimmune regulator.
Immunity, in press.
2007
Kishida, T., Hiromura, Y., Shin-Ya, M., Asada, H., Kuriyama, H., Sugai, M., Shimizu, A.,
Yokota, Y., Hama, T., Imanishi, J., Hisa, Y. and Mazda, O.:
IL-21 induces inhibitor of differentiation 2 (Id2) and leads to complete abrogation of anaphylaxis in mice.
J. Immunol., 179: 8554-8561, 2007.

Boos, M.D., Yokota, Y., Eberl, G. and Kee, B.L.:
Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity.
J. Exp. Med, 204: 1119-1130, 2007.

Moskowitz, I.P.G., Kim, J.B., Moore, M.L., Wolf, C.M., Peterson, M.A.,
Schendure, J., Nobrega, M.A., Yokota, Y., Berul, C., Izumo, S., Seidman, J.G. and Seidman, C.E.:
A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Cell, 129: 1365-1376, 2007.

Bai, G., Sheng, N., Bian, W., Xie, Z., Yokota, Y., Benezra, R., Kageyama, R., Guillemot, F., Jing, N.:
A novel mechanism of neural stem cell maintenance through sustaining Hes1 expression by Id proteins.
Dev.Cell, 13(2): 283-97, 2007.

Fujimoto, S., Ikawa, T., Kina, T. and Yokota, Y.:
Forced expression of Id2 in fetal thymic T cell progenitors allows some of their progeny to adopt NK cell fate.
Int Immunol, 19(10): 1175-82,2007.

Wang, K.-R., Nemoto, T. and Yokota, Y.:
RFX1 mediates the serum-induced immediate early response of Id2 gene expression.
J. Biol. Chem, 282(36): 26167-77, 2007.

2006
Kim,H.-J.,Kim,N.-S.,Koo,B.-K.,Kwon,M.-C.,Cho,Y.,Yokota,Y.,Penninger,J.M.and Kong Y.-Y.:
Receptor activateor of NF-kB ligand regulates the proliferation of mammary epithelial cells via Id2.
Mol.Cell.Biol, 26: 1002-1013, 2006.

Lee,J.,Kim,K.,Kim,J.H.,Jin,H.-M.,Choi,H.K.,Lee,S.-H.,Kook,H.,Kim,K.K.,Yokota,Y.,Lee,S.Y.,Choi,Y.and Kim,N.:
Id helix-loop-helix proteins negativery regulate TRANCE-mediated osteoclast differentiation.
Blood, 107: 2686-2693, 2006.

Kitajima,K.,Takahashi,R.and Yokota.Y.:
Localization of Id2 mRNA in the adult mouse brain.
Brain Res, 1073-1074C: 93-102, 2006.

Kimoto,H.,Fujii,Y.,Hirano,S.,Yokota,Y.and Taketo,A.:
Genetic and biochemical properties of stretococcalNAD-glycohydrolaseinhibitor.
J. Biol. Chem, 281: 9181-9189, 2006

Makita,J.,Kurooka,H.,Mori,K.,Akagi,Y.and Yokota,Y.:
Identification of the nuclear export signal in the carboxyl terminal region of Id1.
FEBS Lett, 580: 1812-1816, 2006.

Onken, M.D., Ehlers, J.P., Worley, L.A., Makita, J., Yokota, Y. and Harbour, J.W.:
Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas.
Cancer Res., 66: 4602-4609, 2006.

Marinkovic, T., Garin, A., Yokota, Y., Fu, Y.X., Ruddle, N.H., Furtado, G.C. and Lira, S.A.:
Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid.
J. Clin. Invest., 116: 2622-2632, 2006.

2005
Kimoto, H., Fujii, Y., Yokota, Y. and Taketo, A.:
Molecular characterization of NADase-streptolysin O operon
of hemolytic Streptococci.:
Biochim. Biophys. Acta, 1681: 134-149, 2005.

Kurooka, H. and Yokota, Y.:
Nucleo-cytoplasmic shuttling of Id2,
a negative regulator of basic helix-loop-helix transcription factors.
J. Biol. Chem, 280: 4313-4320, 2005.

Kusunoki, T., Sugai, M., Gonda, H., Nambu, Y., Nakajima-Nagata, N., Katakai, T.,
Kusunok, M., Sakamoto, A., Tokuhisa, T., Nakahata, T., Yokota, Y. and Shimizu, A.:
CpG inhibits IgE class switch recombination through suppression of NF-kB and Irf4 activities,
but not through Id2 or Bcl6.
Biochem. Biophys. Res. Commun. 328: 499-506, 2005.

Sugai, M., Gonda, H., Nambu, Y., Yokota, Y. and Shimizu, A.:
Accessibility control of recombination at immunoglobulin locus.
Curr. Immunol. Rev, 1: 69-79, 2005.

Karaya, K., Mori, S., Kimoto, H., Shima, Y., Tsuji, Y., Kurooka, H., Akira, S. and Yokota, Y.:
Regulation of Id2 expression by CCAAT/enhancer binding protein ƒÀ.
Nucleic Acids Res, 33: 1924-1934, 2005.

Li,X., Kimura,H., Hirota,K., Kasuno,K., Torii,K., Okada,T., Kurooka,H., Yokota,Y. and Yoshida,H.:
Synergistic effect of hypoxia and tumor necrosis factor-ƒ¿ on production of plasminogen activator inhibitor-1
in human proximal renal tubular cells.
Kidney Int, 68: 569-583, 2005.

Lasorell, A., Rothschild, G., Yokota. Y., Russell, R.G. and Iavarone,A.:
Id2 mediates tumor initiation,proliferation,andangiogenesisin Rb mutant mice.
Mol.Cell.Biol, 25: 3563-3574, 2005.

Kimoto,H., Fujii,Y., Hirano,S., Yokota,Y. and Taketo,A.:
Expression of recombinant streptolysin O and specific antibody production.
J.Mol Microbiol Biotech, 10: 64-68, 2005.

2004
Kim, J.-K., Takeuchi, M. and Yokota, Y.:
Impairment of Intestinal intraepithelial lymphocytes in Id2 deficient mice.
Gut, 53: 480-486, 2004.

Jang, M.H., Kweon, M.N., Iwatani, K., Yamamoto, M., Sasakawa, C., Suzuki, T., Kraehenbuhl, J.-P.,
Yokota, Y., Rennert, P.D., Iijima, H., Kunisawa, J. and Kiyono, H.:
Intestinal villous bacteria translocation islands:
a new antigen entry site in the mucosal epithelium.
Proc. Natl. Acad. Sci. USA, 20: 6110-6115, 2004.

Inouye, S., Izu, H., Takaki, E., Suzuki, H., Shirai, M., Yokota, Y.,
Ichikawa, H., Fujimoto, M and Nakai A.:
Impaired IgG production in mice deficient for heat shock transcription factor 1.
J. Biol. Chem., 279: 38701-38709, 2004.

Sugai, M., Gonda, H., Nambu, Y., Yokota, Y. and Shimizu, A.:
Role of Id proteins in B cell activation: new insights from knockout mouse studies.
J. Mol. Med, 82: 592-599, 2004.

Aoki, Y., Mori, S., Kitajima, K., Yokoyama, O., Kanamaru, H., Okada, K. and Yokota, Y.:
Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans.
Genes to Cells, 9: 1287-1296, 2004.

Nilsson, J.A., Nilsson, L., Keller, U.B., Yokota, Y., Boyd, K. and Cleveland, J.L.:
Id2 is dispensable for Myc-induced lymphomagenesis.
Cancer Res, 64: 7296-7301, 2004.

Marino, S., Romelfanger, C., Yokota, Y. and Nusse, R.:
Wnt1 expression is epistatic to Id2 in modeling mammary gland development
and in causing mammary tumors.
BMC Cancer, 4: 91, 2004

2003
Kusunoki, T., Sugai, M., Katakai, T., Omatsu, Y., Iyoda, T.,
Inaba, K., Nakahata, T., Shimizu, A. and Yokota, Y.:
TH2 dominance and defective development of CD8+ dendritic cell
subset in Id2-deficient mice.
J. Allergy Clin. Immunol, 111: 136-142, 2003.

Sugai, M., Gonda, H., Kusunoki, T., Katakai, T., Yokota, Y. and Shimizu, A.:
Essential role of Id2 in negative regulation of IgE class switching.
Nat. Immunol, 4: 25-30, 2003.

Hacker, C., Kirsch, R.D., Ju, X.-S., Hieronymus, T., Gust, T.C.,
Kuhl, C., Jorgas, T., Kurz, S.M., Rose-John, S., Yokota, Y. and Zenke, M.:
Transcriptional profiling identifies Id2 function in dendritic cell development.
Nat. Immunol, 10: 380-386, 2003.

Mori, S., Inoshima, K., Shima, Y., Schmidt, E.V. and Yokota, Y.:
Forced expression of cyclin D1 does not compensate for
Id2 deficiency in the mammary gland.
FEBS Lett, 551: 123-127, 2003.

Gonda, H., Sugai, M., Nambu, Y., Katakai, T., Agata, Y.,
Mori, K.J., Yokota, Y. and Shimizu, A.:
The balance between Pax5 and Id2 activities is the key to AID gene expression.
J. Exp. Med, 198: 1427-1437.

Nambu, Y., Sugai, M., Gonda, H., Lee, C.-G., Katakai, T.,
Agata, Y., Yokota, Y. and Shimizu, A.:
Transcription-coupled events associating with immunoglobulin switch region chromatin.
Science, 302: 2137-2140.

2002
Greichmann, M., Buchheim, G., El-Bizri, H., Yokota, Y.,
Klockgether, T., Kugler, S., Bahr, M., Weller, M. and Schulz, J.B.:
Identification of inhibitor-of-differentiation 2
as a modulator of neuronal apoptosis.
J. Neurochem, 80: 755-762, 2002.

Lasorella, A., Boldrini, R., Dominici, C., Donfrancesco, A., Yokota, Y., Inserra, A. and Iavarone, A.:
Id2 is critical for cellular proliferation and is the oncogenic effector
of N-myc in human neuroblastoma.
Cancer Res, 62: 301-306, 2002.

Yokota, Y. and Mori, S. :
The role of Id family proteins in growth control.
J. Cell. Physiol, 190: 21-28, 2002.

Fukuyama, S., Hiroi, T., Yokota, Y., Rennert, P. D., Yanagita, M., Kinoshita, N., Terawaki, S., Shikina, T., Yamamoto, M., Kurono, Y. and Kiyono, H.:
Initiation of NALT organogenesis is independent of the IL-7R, LTa1b2/LTbR and
NIK signaling pathways but does require the Id2 gene and
CD3-CD4+CD45+ cells.
Immunity, 17: 31-40, 2002.

Kimoto, H., Kusaoke, H., Yamamoto, I., Fujii, Y., Onodera, T. and Taketo, A.:
Biochemical and genetic properties of Paenibacillus glycosyl hydrolase
having chitosanase activity and discoidin domain.
J. Biol. Chem, 277: 14695-14702, 2002.

Kakikawa, M., Yokoi, K., Kimoto, H.,
Nakano, M., Kawasaki, K., Taketo, A. and Kodaira, K.:
Molecular analysis of the lysis protein Lys
encoded by Lactobacillus plantarum phage ƒÓg1e.
Gene, 299: 227-34, 2002.

Okuda, Y., Takahashi, I., Kim, J-K., Ohta, N., Iwatani, K., Iijima, H., Kai, Y., Tamagawa, H.,
Hiroi, T., Kweon, M-N., Kawano, S., Takeda, K., Akira, K., Sasaki, Y., Hori, M., and Kiyono, H.:
Development of colitis in signal transducers and activators
of transcription 6-deficient T-cell receptor alpha-deficient mice:
a potential role of signal transducers and activators of transcription 6-independent
interleukin-4 signaling for the generation of Th2-biased pathological CD4+ bb T cells.
Am. J. Pathol, 162: 263-71, 2002.

2001
Ikawa, T., Fujimoto, S., Kawamoto, H., Katsura, Y. and Yokota, Y. :
Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2.
Proc. Natl. Acad. Sci. USA, 98: 5164-5169, 2001

Wang, S., Sdrulla, A., Johnson, J. E., Yokota, Y. and Barres, B. A. :
A role for the helix-loop-helix protein Id2 in the control of
oligodendrocyte development.
Neuron, 29: 603-614, 2001

Fujii, Y., Kimoto, H., Ishikawa, K., Watanabe, K., Yokota, Y., Nakai, N. and Taketo, A.:
Taxon-specific zeta-crystallin in Japanese tree frog (Hyla japonica) lens.
J. Biol. Chem, 276: 28134-28139, 2001.

Tachibana, M., Narumi, O., Muguruma, K, Yamamoto, I., Shinkai, Y. and Yokota, Y.:
Genomic organization and chromosomal mapping of
the basic helix-loop-helix factor OUT (Tcf23/TCF23).
Cytogenet. Cell Genet, 94: 23-25, 2001.

Yokota, Y., Mori, S., Narumi, O. and Kitajima, K. :
In vivo function of a differentiation inhibitor, Id2.
IUBMB Life, 51: 207-214, 2001.

Mansouri, A., Yokota Y. and Gruss, P.:
Uncx4.1 is required for sclerotome condensation.
In "The Origin and Fate of Somites", eds. Sanders, E. J., Lash, J. W. and Ordahl, C. P.,
NATO Science Series, Series I: Life and Behavioural Sciences, vol. 329, pp. 174-181, IOS Press, Amsterdam, 2001.

Yokota, Y. :
Id and development.
Oncogene, 20: 8290-8298, 2001.

Karaya, K., Shimizu, T., and Taketo, A.:
New gene cluster for lantibiotic streptin possibly involved in
streprolysin S formation.
J. Biochem. 129: 769-775, 2001.

Tajima, H., Kimoto, H., Taketo, A.:
Specific antimicrobial synergism of synthetic hydroxy isothiocyanates
with aminoglycoside antibiotics.
Biosci. Biotech. Biochem, 65: 1886-1888, 2001.

2000
Narumi, O., Mori, S., Boku, S., Tsuji, Y., Hashimoto, N.,
Nishikawa, S.-I. Yokota, Y. :
OUT, a novel basic helix-loop-helix transcription factor
with an Id-like inhibitory activity.
J. Biol. Chem. 275: 3510-3521, 2000

Kataoka, H., Murayama, T., Yokode, M., Mori, S., Sano, H., Ozaki, H.,
Yokota, Y., Nishikawa, S.- I. and Kita, T. :
A novel Snail-related transcription factor Smuc regulates basic helix-loop-helix
transcription factor activities via specific E-box motifs.
Nucleic Acids Res. 28: 626-633, 2000

Mansouri, A., Voss, A. K., Thomas, T., Yokota, Y. and Gruss, P. :
Uncx4.1 is required for the formation of the pedicles and proximal ribs
and acts upstream of Pax9.
Development, 127: 2251-2258, 2000

Mori, S., Nishikawa, S.-I. and Yokota, Y. :
Lactation defect in mice lacking the helix-loop-helix inhibitor Id2.
EMBO J, 19: 5772-5781, 2000

Lasorella, A., Noseda, M., Beyna, M., Yokota, Y. and Iavarone, A. :
Id2 is a Retinoblastoma protein target and mediates signalling by Myc oncoproteins.
Nature, 407: 592-598, 2000@

Yokota, Y., Mori, S., Nishikawa, S.-I., Mansouri, A., Gruss, P.,
Kusunoki, T., Katakai, T. and Shimizu, A. :
The helix-loop-helix inhibitor Id2 and cell differentiation control.
Curr. Top. Microbiol. Immunol. 251: 35-41, 2000

1999
Mori, S., Sugawara, S., Kikuchi, T., Tanji, M., Narumi, O., Stoykova, A.,
Nishikawa, S.-I., and Yokota, Y. :
The leukemic oncogene tal-2 is expressed in the developing mouse brain.
Mol. Brain Res, 64: 199-210, 1999

Yokota, Y., Mansouri, A., Mori, S., Sugawara, S., Adachi, S.,
Nishikawa, S.-I., and Gruss, P. :
Development of peripheral lymphoid organs and natural killer cells
depends on the helix-loop-helix inhibitor Id2.
Nature, 397: 702-706, 1999