2011年
  • Chihara, K., Nakashima, K., Takeuchi, K., and Sada, K.
  • Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-alpha in RBL-2H3 cells.
  • Genes Cells. 16(12):1133-1145 (2011)
  • [Abstract]
  • Nakashima, K., Takeuchi, K., Chihara, K., Hotta, H., and Sada, K.
  • Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and -independent pathways.
  • Microbiol. Immunol. 55(11):774-782 (2011)
  • [Abstract]
  • Ogi, K., Nakashima, K., Chihara, K., Takeuchi, K., Horiguchi, T., and Sada, K.
  • Enhancement of B cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism.
  • Genes Cells. 16(9):951-960 (2011)
  • [Abstract]
  • Horiguchi, T., Ishiguro, N., Chihara, K., Ogi, K., Nakashima, K., Sada, K., and Hori-Tamura, N.
  • Inhibitory effect of Acai pulp on IgE-mediated mast cell activation.
  • J. Agric. Food Chem. 59(10):5595-5601 (2011)
  • [Abstract]

　2010年
  • 千原一泰, 定　清直.
  • 関節リウマチ治療におけるSyk阻害薬の可能性を探る.
  • 分子リウマチ治療　3(4):186-189 (2010)
  • 定　清直.
  • C型肝炎ウイルスの病原性発現機構.
  • 小児感染免疫 22(1): 35-41 (2010)

　2009年
  • Shukla, U., Hatani, T., Nakashima, K., Ogi, K., and Sada, K.
  • Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT.
  • J. Biol. Chem. 284(49):33719-33728 (2009)
  • [Abstract]
  • 2009年7月〜12月における優秀論文（福井大学医学部）に選出
  • Qu, X., Zhang, Y., Li, Y., Hu, X., Xu, Y., Xu, L., Hou, K., Sada, K., and Liu, Y
  • Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals.
  • FEBS lett. 583(13):2255-2262 (2009)
  • [Abstract]
  • Zhang, Y., Qu, X., Hu, X., Yang, X., Hou, K., Teng, Y., Zhang, J., Sada, K., and Liu, Y
  • Reversal of P-glycoprotein mediated multidrug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocartinoma cells.
  • J. Pathol. 218(2):248-255 (2009)
  • [Abstract]
  • Xu, L., Qu, X., Zhang, Y., Hu, X., Yang, X., Hou, K., Teng, Y., Zhang, J., Sada, K., and Liu, Y
  • Oxaliplatin enhances TRAIL-induced apoptotis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts.
  • FEBS lett. 583(5):943-948 (2009)
  • [Abstract]
  • Kasai, D., Adachi, T., Deng, L., Nagano-Fujii, M., Sada, K., Ikeda, M., Kato, N., Ide, Y., Shoji, I., and Hotta, H.
  • HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters.
  • J. Hepatol. 50(5):883-894 (2009)
  • [Abstract]
  • 羽溪朋子, 定　清直.
  • Syk阻害剤. 特集 低分子抗炎症薬
  • 炎症と免疫 17(5): 48-55 (2009)
　　2008年
  • Takeuchi, K., Komatsu, T., Kitagawa, Y., Sada, K., and Gotoh, B.
  • A role of Sendai virus C protein in restricting PKR activation: Limitation of intracellular double stranded RNA generation.
  • J. Virol. 82(20):10102-10110 (2008)
  • [Abstract]
  • Inubushi, S., Nagano-Fujii, M., Kitayama, K., Tanaka, M., An, C., Yokozaki, H., Yamamura, H., Nuriya, H., Kohara, M., Sada, K., and Hotta, H.
  • Hepatitis C virus protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk.
  • J. Gen. Virol. 89(5):1231-1242 (2008)
  • [Abstract]
  • Hatani, T. and Sada, K.
  • Adaptor protein 3BP2 and cherubism.
  • Curr. Med. Chem. 15(6):549-554 (2008)
  • [Abstract]
　　以前の業績

　　欧文原著・総説
  • Yonashiro, R., Ishido, S., Kyo, S., Fukuda, T., Goto, E., Matsuki, Y., Ohmura-Hashimoto, M., Sada, K., Hotta, H., Yamamura, H., Inatome, R. and Yanagi, S.
  • A novel mitochondria ubiquitin ligase plays a critical role in mitochondrial dynamics.
  • EMBO J. 25(15):3618-3626 (2006)
  • [Abstract] [Full text]
  • Hotta, H., Nihei, K., Abe, Y., Kato, S., Jiang D. P., Nagano-Fujii, M., and Sada, K.
  • Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE.
  • Microbiol. Immunol. 50(7):525-534 (2006)
  • [Abstract]
  • Nomura-Takigawa, Y., Nagano-Fujii, M., Deng, L., Kitazawa, S., Ishido, S., Sada, K., and Hotta, H.
  • The nonstructural protein 4A of hepatitis C virus accumulates on mitochondria and induces apoptotic cell death through a mitochondria-mediated pathway.
  • J. Gen. Virol. 87(7):1935-1945 (2006)
  • [Abstract] [Full text]
  • Deng, L., Nagano-Fujii, M., Tanaka, M., Nomura-Takigawa, Y., Ikeda, M., Kato, N., Sada, K., and Hotta, H.
  • The NS3 protein of hepatitis C virus associates with the tumor suppressor p53 and inhibits its function in an NS3 sequence-dependent manner.
  • J. Gen. Virol. 87(6):1703-1713 (2006)
  • [Abstract] [Full text]
  • Otaki, M., Sada, K., Kadoya, H., Nagano-Fujii, M., and Hotta, H.
  • Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference.
  • Antiviral Res. 70(3):105-111 (2006)
  • [Abstract]
  • Tanaka, M., Nagano-Fujii, M., Deng, L., Ishido, S., Sada, K., and Hotta, H.
  • Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3.
  • Biochem. Biophys. Res. Commun. 340(3):792-799 (2006)
  • [Abstract]
  • Qu, X., Miah, S. M., Hatani, T., Okazaki, M., Hori-Tamura, N., Yamamura, H. Hotta, H., and Sada, K.*
  • Selective inhibition of Fc(epsilon)RI-mediated mast cell activation by a truncated variant of Cbl-b related to the rat model of type 1 diabetes mellitus.
  • J. Biochem. 137(6):711-720 (2005)
  • [Abstract]
  • Qu, X., Kawauchi-Kamata, K., Miah, S. M., Hatani, T., Yamamura, H., and Sada, K.*
  • Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.
  • Biochemistry 44(10):3891-3898 (2005)
  • [Abstract] [Full text]
  • Miah, S. M., Hatani, T., Qu, X., Yamamura, H., and Sada, K.*
  • Point mutations of 3BP2 identified in human inherited disease cherubism result in the loss of function.
  • Genes Cells 9(11):993-1004 (2004)
  • [Abstract] [Full text]
  • Enoki, E., Sada, K., Qu, X., Kyo, S., Miah, S. M., Hatani, T., Tomoda, A., and Yamamura, H.
  • The phenoxazine derivative Phx-1 suppresses IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells.
  • J. Pharmacol. Sci. 94(3):329-333 (2004)
  • [Abstract]
  • Qu, X., Sada, K.*, Kyo, S., Maeno, K., Miah, S. M., and Yamamura, H.
  • Negative regulation of Fc(epsilon)RI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b.
  • Blood 103(5):1779-1786 (2004)
  • [Abstract] [Full text]
  • Miah, S. M., Sada, K.*, Tuazon, P. T., Ling, J., Maeno, K., Kyo, S., Qu, X., Tohyama, Y., Traugh, J. A., and Yamamura, H.
  • Activation of Syk protein-tyrosine kinase in response to osmotic stress requires the interaction with p21-activated protein kinase Pak2/(gamma)-PAK.
  • Mol. Cell. Biol. 24(1):71-83 (2004)
  • [Abstract] [Full text]
  • Kyo, S., Sada, K., Qu, X., Maeno, K., Miah, S. M., Kawauchi-Kamata, K., and Yamamura, H.
  • Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc(epsilon)RI-mediated mast cell activation.
  • Genes Cells 8(10):825-836 (2003)
  • [Abstract] [Full text]
  • Maeno, K., Sada, K.*, Kyo, S., Miah, S. M., Kawauchi-Kamata, K., Qu, X., Shi, Y., and Yamamura, H.
  • Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.
  • J. Biol. Chem. 278(27):24912-24920 (2003)
  • [Abstract] [Full text]
  • Sada, K.* and Yamamura, H.
  • Protein-tyrosine kinases and adaptor proteins in Fc(epsilon)RI-mediated signaling in mast cells.
  • Curr. Mol. Med. 3(1):85-94 (2003) Review
  • [Abstract]
  • Asahi, M., Tanaka, Y., Izumi, T., Ito, Y., Naiki, H., Kersulyte, D., Tsujikawa, K., Saito, M., Sada, K., Yanagi, S., Fujikawa, A., Noda, M., and Itokawa Y.
  • Helicobacter pylori CagA containing ITAM-like sequences localized to lipid rafts negatively regulates VacA-induced signaling in vivo.
  • Helicobacter 8(1):1-14 (2003)
  • [Abstract]
  • Gao, S., Takano, T., Sada, K., He, J., Noda, C., Hori-Tamura, N., Tomoda, A., and Yamamura, H.
  • A novel phenoxazine derivative suppresses surface IgM expression in DT40 B cell line.
  • Brit. J. Pharmacol. 137(6):749-755 (2002)
  • [Abstract] [Full text]
  • Takano, T., Sada, K., and Yamamura, H.
  • Role of protein-tyrosine kinase Syk in oxidative stress signaling in B cells.
  • Antioxid. Redox Signal. 4(3):533-540 (2002) Review
  • [Abstract]
  • He, J., Takano, T., Ding, J., Gao, S., Noda, C., Sada, K.Sada, K., Yanagi, S., and Yamamura, H.
  • Syk is required for p38 activation and G2/M arrest in B cells exposed to oxidative stress.
  • Antioxid. Redox Signal. 4(3):509-515 (2002)
  • [Abstract]
  • Sada, K.*, Miah, S. M., Maeno, K., Kyo, S., Qu, X., and Yamamura, H.
  • Regulation of Fc(epsilon)RI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells.
  • Blood 100(6):2138-2144 (2002)
  • [Abstract] [Full text]
  • Siraganian, R. P., Zhang, J., Suzuki, K., and Sada, K.
  • The role of protein tyrosine kinase Syk in mast cell signaling.
  • Mol. Immunol. 38(16-18):1229-1233 (2002) Review
  • [Abstract]
  • Sada, K., Takano, T., Yanagi, S., and Yamamura, H.
  • Structure and function of Syk protein-tyrosine kinase.
  • J. Biochem. 130(2):177-186 (2001) Review
  • [Abstract]
  • Sada, K.*, Zhang, J., and Siraganian, R. P.
  • SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for Fc(epsilon)RI signaling.
  • Blood 97(5):1352-1359 (2001)
  • [Abstract] [Full test]
  • Sada, K.*, Zhang, J., and Siraganian, R. P.
  • Point mutation of a tyrosine in the linker region of Syk results in a gain of function.
  • J. Immunol. 164(1):338-344 (2000)
  • [Abstract] [Full test]
  • Maruo, A., Oishi, I., Sada, K., Nomi, M., Kurosaki, T., Minami, Y., and Yamamura, H.
  • Protein tyrosine kinase lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells.
  • Int. Immunol. 11(9):1371-1380 (1999)
  • [Abstract]
  • Rezaul, K., Sada, K., and Yamamura, H.
  • Involvement of reactive oxygen intermediates in lectin-induced protein-tyrosine phosphorylation of Syk in THP-1 cells.
  • Biochem. Biophys. Res. Commun. 246(3):863-867 (1998)
  • [Abstract]
  • Rezaul, K., Sada, K., Inazu, T., and Yamamura, H.
  • Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line.
  • Biochem. Biophys. Res. Commun. 239(1):23-27 (1997)
  • [Abstract]
  • Sada, K., Minami, Y., and Yamamura, H.
  • Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak.
  • Eur. J. Biochem. 248(3):827-833 (1997)
  • [Abstract]
  • Nakamura, T., Koyama, M., Yoneyama, A., Higashihara, M., Kawakami, T., Yamamura, H., Sada, K., Okumura, K., and Kurokawa, K.
  • Signal transduction through (mu kappa) B-cell receptors expressed on pre-B cells is different from that through B-cell receptors on mature B cells.
  • Immunology 88(4):593-899 (1996)
  • [Abstract]
  • Maruyama, S., Kurosaki, T., Sada, K., Yamanashi, Y., Yamamoto, T., and Yamamura, H.
  • Physical and functional association of cortactin with Syk in human leukemic cell line K562.
  • J. Biol. Chem. 271(12):6631-6635 (1996)
  • [Abstract] [Full test]
  • Kurosaki, T., Johnson, S. A., Pao, L., Sada, K., Yamamura, H., and Cambier, J. C.
  • Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.
  • J. Exp. Med. 182(6):1815-1823 (1995)
  • [Abstract]
  • Asahi, M., Tanaka, Y., Qin, S., Tsubokawa, M., Sada, K., Minami, Y., and Yamamura, H.
  • Cyclic AMP-elevating agents negatively regulate the activation of p72syk in N-formyl-methionyl-leucyl-phenylalanine receptor signaling.
  • Biochem. Biophys. Res. Commun. 212(3):887-893 (1995)
  • [Abstract]
  • Ozaki, Y., Satoh, K., Kuroda, K., Qi, R., Yatomi, Y., Yanagi, S., Sada, K., Yamamura, H., Yanabu, M., Nomura, S., and Kume, S.
  • Anti-CD9 monoclonal antibody activates p72syk in human platelets.
  • J. Biol. Chem. 270(25):15119-15124 (1995)
  • [Abstract]
  • Minami, Y., Nakagawa, Y., Kawahara, A., Miyazaki, T., Sada, K., Yamamura, H., and Taniguchi, T.
  • Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway.
  • Immunity 2(1):89-100 (1995)
  • [Abstract]
  • Tohyama, Y., Yanagi, S., Sada, K., and Yamamura, H.
  • Translocation of p72syk to the cytoskeleton in thrombin-stimulated platelets.
  • J. Biol. Chem. 269(52):32796-32799 (1994)
  • [Abstract]
  • Rezaul, K., Yanagi, S., Sada, K., Taniguchi, T., and Yamamura, H.
  • Protein-tyrosine kinase p72syk is activated by platelet activating factor in platelets.
  • Thromb. Haemost. 72(6):937-941 (1994)
  • [Abstract]
  • Fujii, C., Yanagi, S., Sada, K., Nagai, K., Taniguchi, T., and Yamamura, H.
  • Involvement of protein-tyrosine kinase p72syk in collagen-induced signal transduction in platelets.
  • Eur. J. Biochem. 226(1):243-248 (1994)
  • [Abstract]
  • Wang, X., Sada, K., Yanagi, S., Yang, C., Rezaul, K., and Yamamura, H.
  • Intracellular calcium dependent activation of p72syk in platelets.
  • J. Biochem. 116(4):858-861 (1994)
  • [Abstract]
  • Yanagi, S., Sada, K., Tohyama, Y., Tsubokawa, M., Nagai, K., Yonezawa, K., and Yamamura, H.
  • Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation.
  • Eur. J. Biochem. 224(2):329-333 (1994)
  • [Abstract]
  • Qin, S., Inazu, T., Yang, C., Sada, K., Taniguchi, T., and Yamamura, H.
  • Interleukin 2 mediates p72syk activation in peripheral blood lymphocytes.
  • FEBS Lett. 345(2-3):233-236 (1994)
  • [Abstract]
  • Tsubokawa, M., Yanagi, S., Sada, K., Nakamura, S., Saito, H., and Yamamura, H.
  • CPTK71, a cytosolic protein-tyrosine kinase previously purified from bovine platelets, is identical with p72syk.
  • Biochem. Biophys. Res. Commun. 200(3):1592-1597, (1994)
  • [Abstract]
  • Sada, K., Yanagi, S., and Yamamura, H.
  • Activation of p72syk by thrombin in a cell-free system.
  • Biochem. Biophys. Res. Commun. 200(1):1-7 (1994)
  • [Abstract]
  • Takeuchi, N., Hashimoto, E., Nakamura, T., Takeuchi, F., Sada, K., and Yamamura, H.
  • Possible role of Na+ influx in phorbol ester-induced down-regulation of protein kinase C in HL60 cells.
  • FEBS Lett. 328(3):280-284 (1993)
  • [Abstract]
  • Sakai, K., Sada, K., Tanaka, Y., Kobayashi, T., Nakamura, S., and Yamamura, H.
  • Regulation of cytosolic protein-tyrosine kinase from porcine spleen by polyamines and negative-charged polysaccharides.
  • Biochem. Biophys. Res. Commun. 154(3):883-889 (1988)
  • [Abstract]
  • Sakai, K., Nakamura, S., Sada, K., Kobayashi, T., Uno, H., and Yamamura, H.
  • Characterization of partially purified cytosolic protein-tyrosine kinase from porcine spleen.
  • Biochem. Biophys. Res. Commun. 152(3):1123-1130 (1988)
  • [Abstract]
  • * corresponding author
　　和文総説
  • 定　清直.
  • マスト細胞活性化シグナルを制御する分子. 特集 マスト細胞とアレルギー.
  • Molecular Medicine　42(10):1107-1112 (2005)
  • 定　清直.
  • 肥満細胞におけるFc(epsilon)レセプターIからのシグナル伝達：3BP2とCbl-bによる肥満細胞活性化制御. 総説.
  • 臨床免疫　44(1):63-70 (2005)
  • 定　清直.
  • マスト細胞学の分子生物学-IgEシグナルを中心に-. 特集 好酸球及びマスト細胞の最近の進歩.
  • アレルギーの臨床　24(10):781-785 (2004)
  • 定　清直.
  • マスト細胞の負の活性制御因子. 特集 マスト細胞活性化機構研究の新しい展開-マスト細胞にアレルギー治療の分子標的を求めて.
  • アレルギー科　17(3):220-227, 17(4):403 (2004)
  • 定　清直, 鎌田敬子.
  • マスト細胞におけるアダプター分子3BP2の役割. 特集 マスト細胞活性化の新知見.
  • アレルギー科　13(3): 203-210 (2003)
  • 定　清直, 山村博平.
  • 血液免疫系細胞に発現するチロシンキナーゼSykの生理的役割. 話題.
  • 医学のあゆみ　181:1078-1079 (1997)
  • 定　清直, 圓尾明弘, 南　康博, 山村博平.
  • 非受容体型チロシンキナーゼSykの構造と生理的役割. 解説.
  • アレルギー科　3:100-106 (1997)
  • 南　康博, 定　清直, 大石　勲, 山村博平.
  • 血液・免疫系細胞の活性化・増殖および細胞死の過程におけるチロシンキナーゼの役割.
  • 蛋白質核酸酵素　増刊「細胞周期の分子機構」　41:1666-1672 (1996)
  • 定　清直, 南　康博, 山村博平.
  • Syk/ZAP-70ファミリーチロシンキナーゼの機能と活性制御.
  • 実験医学　増刊「免疫のシグナル伝達」　14:753-757 (1996)
  • 柳　茂, 定　清直, 山村博平.
  • 血液・免疫系に発現するチロシンキナーゼp72sykの新しい展開. 総説.
  • 生化学　66:1219-1229 (1994)
　　その他
  • 定　清直.
  • 非血液免疫系細胞におけるSykの機能解析. 上原記念生命科学財団研究報告集. 16:251-253 (2002)