福井大学医学部

ゲノム科学・微生物学

研究業績

学術論文については各教員が当研究室に所属する以前のものも含んでいます。 ※体裁について調整中です(2019.04.09)

学術論文・著書

2019

  1. Muramatsu, I., Uwada, J., Yoshiki, H., Sada, K., Lee, K. S., Yazama, T., Taniguchi, T, Nishio, M., Ishibashi, T., and Masuoka, T. Novel regulatory systems for acetylcholine release in rat striatum and anti-Alzheimer’s disease drugs. J. Neurochem. in press.

2018

  1. Muramatsu, I., Masuoka, T., Uwada, J., Yoshiki, H., Yazama, T., Lee, K. S., Sada, K., Nishio, M., Ishibashi, T., and Taniguchi, T. A new aspect of cholinergic transmission in the central nervous system. In: Akaike A., Shimohama S., Misu Y. (eds) Nicotinic Acetylcholine Receptor Signaling in Neuroprotection, page 45-58 (chapter 3) 2018, DOI 10.1007/978-981-10-8488-1_3, Springer, Singapore
  2. Kowada, K., Takeuchi, K., Hirano, E., Toho, M., and Sada, K. Development of a Multiplex Real-Time PCR Assay for Detection of Human Enteric Viruses Other Than Norovirus Using Samples Collected from Gastroenteritis Patients in Fukui Prefecture, Japan. J. Med. Virol. 90(1):67-75, 2018.

2017

  1. Chihara, K.Kato, Y.Yoshiki, H.Takeuchi, K., Fujieda, S., and Sada, K. Syk-dependent tyrosine phosphorylation of 3BP2 is required for FcRγ-mediated phagocytosis and chemokine expression in U937 cells. Sci. Rep. 7(1):11480, 2017.
  2. Takahashi, N., Saeki, T., Komatsuda, A., Munemura, C., Fukui, T., Imai, N., Homma, N., Hatta, T., Samejima, K., Fujimoto, T., Omori, H., Ito, Y., Nishikawa, Y., Kobayashi, M., Morikawa, Y., Fukushima, S., Yokoi, S., Mikami, D., Kasuno, K., Kimura, H., Nemoto, T., Nakamoto, Y.,Sada, K., Sugai, M., Naiki, H., Yoshida, H., Narita, I., Saito, Y., and Iwano, M. Tubulointerstitial nephritis with IgM-positive plasma cells. J. Am. Soc. Nephrol. 28(12):3688-3698, 2017.
  3. Muramatsu, I., Uwada, J., Masuoka, T., Yoshiki, H.Sada, K., Nishio, M., Ishibashi, T., and Taniguchi, T. Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission. J. Neurochem. 143(1):76-86, 2017.
  4. Uwada, J., Yazawa, T., Islam M. T., Khan, M. R. I., Krug, S. M., Fromm, M., Karaki, S., Suzuki, Y., Kuwahara, A., Yoshiki, H.Sada, K.Muramatsu, I., and Taniguchi, T. Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK. Cell. Signal. 35:188-196, 2017.
  5. Honjoh, C.Chihara, K.Yoshiki, H.Yamauchi, S.Takeuchi, K.Kato, Y.,  Hida, Y., Ishizuka, T., and Sada, K. Association of C-type lectin Mincle with FcεRIβγ subunits leads to functional activation of rat mast cells through Syk protein tyrosine kinase. Sci. Rep. 7:46064, 2017.

2016

  1. Yamauchi, S.,Takeuchi, K.,Chihara, K.,Honjoh, C.,Kato, Y.,Yoshiki, H., Hotta, H., and Sada, K. STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α. Sci. Rep. 6:38336, 2016.
  2. Muramatsu, I.,Yoshiki, H., Uwada, J., Masuoka, T.,Sada, K., Taniguchi, T., and Nishio, M. Pharmacological evidence of specific acetylcholine transport in rat cerebral cortex and other brain regions. J. Neurochem. 139(4):566-575, 2016.

2015

  1. Yamauchi, S.Takeuchi, K.Chihara, K.Sun, X.Honjoh, C.Yoshiki, H., Hotta, H. and Sada, K. Hepatitis C virus particle assembly involves phosphorylation of NS5A by the c-Abl tyrosine kinase. J. Biol. Chem. 290(36):21857-21864, 2015.
  2. Muramatsu, I.Yoshiki, H.Sada, K., Uwada, J., Taniguchi, T., Masuoka, T., and Nishio, M. Binding method for detection of muscarinic acetylcholine receptors in receptor’s natural environment. Myslivecek J and Jakubik J (eds.) Muscarinic Receptor: From Structure to Animal Models, Neuromethods, vol. 107, page 69-81 (chapter 4), 2015, DOI 10.1007/978-1-4939-2858-3_4, Springer (Humana Press)
  3. Khan, M. R. I., Uwada, J., Yazawa, T., Islam, M. T., Krug, S. M., Fromm, M., Karaki, S., Suzuki, Y., Kuwahara, A.,Yoshiki, H.,Sada, K.,Muramatsu, I., Anisuzzaman, A. S. M., and Taniguchi, T. Activation of muscarinic cholinoceptor ameliorates tumor necrosis factor-α-induced barrier dysfunction in intestinal epithelial cells. FEBS Lett. 589(23):3640-7, 2015.

2014

  1. Kimura, Y.Chihara, K.Honjoh, C.Takeuchi, K.Yamauchi, S.Yoshiki, H., Fujieda, S., and Sada, K. Dectin-1-mediated Signaling Leads to Characteristic Gene Expressions and Cytokine Secretion via Syk in Rat Mast Cells. J. Biol. Chem. 289(45):31565-31575, 2014.
  2. Chihara, K.Kimura, Y.Honjoh, C.Yamauchi, S.Takeuchi, K., and Sada, K. Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with Vav3 in chicken DT40 cells. Exp. Cell Res. 322(1):99-107, 2014.

2012

  1. Nakashima, K.Takeuchi, K.Chihara, K.Horiguchi, T.Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K. HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells. PLoS One 7(10): e46634, 2012.

2011

  1. Horiguchi, T., Ishiguro, N., Chihara, K.Ogi, K.Nakashima, K.Sada, K., and Hori-Tamura, N. Inhibitory effect of Acai (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation. J. Agric. Food. Chem. 59(10):5595-5601, 2011.
  2. Kitagawa, Y., Yamaguchi, M., Zhou, M., Komatsu, T., Nishio, M., Sugiyama, T.,Takeuchi, K., Itoh, M., and Gotoh, B. A Tryptophan-rich motif in the human parainfluenza virus type 2 v protein is critical for the blockade of toll-like receptor 7 (TLR7)- and TLR9-dependent signaling. J. Virol. 85(9):4606-4611, 2011.
  3. Ogi, K.Nakashima, K.Chihara, K.Takeuchi, K.Horiguchi, T.,  Fujieda, S., and Sada, K. Enhancement of B cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism. Genes Cells 16(9):951-960, 2011.
  4. Nakashima, K.Takeuchi, K.Chihara, K., Hotta, H., and Sada, K. Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and -independent pathways. Microbiol. Immunol. 55(11):774-782, 2011.
  5. Chihara, K.Nakashima, K.Takeuchi, K., and Sada, K. Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-alpha in RBL-2H3 cells. Genes Cells. 16(12):1133-1145, 2011.

2010

  1. Hino, S., Kondo, S., Yoshinaga, K., Saito, A., Murakami, T., Kanemoto, S., Sekiya, H.,Chihara, K., Aikawa, Y., Hara, H., Kudo, T., Sekimoto, T., Funamoto, T., Chosa, E., and Imaizumi, K. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. J. Bone Miner. Metab. 28(2), 131-138, 2010.
  2. Kitagawa, Y., Zhou, M., Yamaguchi, M., Komatsu, T.,Takeuchi, K., Itoh, M., and Gotoh, B. Human metapneumovirus M2-2 protein inhibits viral transcription and replication. Microbes Infect. 12(2):135-145, 2010.

2009

  1. Chihara, K., Saito, A., Murakami, T., Hino, S-I., Aoki, Y., Sekiya, H., Aikawa, Y., Wanaka, A., and Imaizumi, K. Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice. J. Neurochem. 110(3), 956-965, 2009.
  2. Murakami, T., Saito, A., Hino, S-I., Kondo,S., Kanemoto, S.,Chihara, K., Sekiya, H., Tsumagari, K., Ochiai, K., Yoshinaga, K., Saitoh, M., Nishimura, R., Yoneda, T., Kou, I., Furuichi, T., Ikegawa, S., Ikawa, M., Okabe, M., Wanaka, A., and Imaizumi, K. Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat. Cell Biol., 11(10), 1205-1211, 2009.
  3. Xu, L., Qu, X., Zhang, Y., Hu, X., Yang, X., Hou, K., Teng, Y., Zhang, J.,Sada, K., and Liu, Y. Oxaliplatin enhances TRAIL-induced apoptotis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts. FEBS lett. 583(5):943-948, 2009.
  4. Kasai, D., Adachi, T., Deng, L., Nagano-Fujii, M.,Sada, K., Ikeda, M., Kato, N., Ide, Y., Shoji, I., and Hotta, H. HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters. J. Hepatol. 50(5):883-894, 2009.
  5. Zhang, Y., Qu, X., Hu, X., Yang, X., Hou, K., Teng, Y., Zhang, J.,Sada, K., and Liu, Y. Reversal of P-glycoprotein mediated multidrug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocartinoma cells. J. Pathol. 218(2):248-255, 2009.
  6. Qu, X., Zhang, Y., Li, Y., Hu, X., Xu, Y., Xu, L., Hou, K.,Sada, K., and Liu, Y. Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals. FEBS lett. 583(13):2255-2262, 2009.
  7. Shukla, U.Hatani, T.Nakashima, K.Ogi, K., and Sada, K. Tyrosine phosphorylation of 3BP2 regulates BCR-mediated activation of NFAT. J. Biol. Chem. 284(49):33719-33728, 2009.

2008

  1. Takeuchi, K.Komatsu, T.,  Kitagawa, Y., Sada, K., and Gotoh, B. Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of
    intracellular double-stranded RNA. J. Virol. 2008 Oct;82(20):10102-10. Epub 2008
    Aug 6. PubMed PMID: 18684815; PubMed Central PMCID: PMC2566265.
  2. Hatani, T. and Sada, K. Adaptor protein 3BP2 and cherubism. Curr. Med. Chem. 15(6):549-554, 2008.
  3. Inubushi, S., Nagano-Fujii, M., Kitayama, K., Tanaka, M., An, C., Yokozaki, H., Yamamura, H., Nuriya, H., Kohara, M.,Sada, K., and Hotta, H. Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk. J. Gen. Virol. 89(5):1231-1242, 2008.

2007

  1. Komatsu TTakeuchi K, and Gotoh B. Bovine parainfluenza virus type 3 accessory
    proteins that suppress beta interferon production. Microbes Infect. 2007
    Jul;9(8):954-62. Epub 2007 Apr 7. PubMed PMID: 17548221.
  2. Hino, S-I., Kondo, S., Sekiya, H., Saito, A., Kanemoto, S., Murakami, T.,Chihara, K., Aoki, Y., Nakamori, M., Takahashi, M. P., and Imaizumi, K. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. Hum. Mol. Genet. 16(23), 2834-2843, 2007

2006

  1. Tanaka, M., Nagano-Fujii, M., Deng, L., Ishido, S.,Sada, K., and Hotta, H. Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3. Biochem. Biophys. Res. Commun. 340(3):792-799, 2006.
  2. Otaki, M., Sada, K., Kadoya, H., Nagano-Fujii, M., and Hotta, H. Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference. Antiviral Res. 70(3):105-111, 2006.
  3. Deng, L., Nagano-Fujii, M., Tanaka, M., Nomura-Takigawa, Y., Ikeda, M., Kato, N.,Sada, K., and Hotta, H. The NS3 protein of hepatitis C virus associates with the tumor suppressor p53 and inhibits its function in an NS3 sequence-dependent manner. J. Gen. Virol. 87(6):1703-1713, 2006.
  4. Nomura-Takigawa, Y., Nagano-Fujii, M., Deng, L., Kitazawa, S., Ishido, S.,Sada, K., and Hotta, H. The nonstructural protein 4A of hepatitis C virus accumulates on mitochondria and induces apoptotic cell death through a mitochondria-mediated pathway. J. Gen. Virol. 87(7):1935-1945, 2006.
  5. Hotta, H., Nihei, K., Abe, Y., Kato, S., Jiang D. P., Nagano-Fujii, M., andSada, K.Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE. Microbiol. Immunol. 50(7):525-534, 2006.
  6. Yonashiro, R., Ishido, S., Kyo, S., Fukuda, T., Goto, E., Matsuki, Y., Ohmura-Hashimoto, M.,Sada, K., Hotta, H., Yamamura, H., Inatome, R. and Yanagi, S. A novel mitochondria ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J. 25(15):3618-3626, 2006.

2005

  1. Qu, X., Kawauchi-Kamata, K., Miah, S. M., Hatani, T., Yamamura, H., and Sada, K. Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor. Biochemistry 44(10):3891-3898, 2005.
  2. Qu, X., Miah, S. M., Hatani, T., Okazaki, M., Hori-Tamura, N., Yamamura, H. Hotta, H., and Sada, K. Selective inhibition of FcRI-mediated mast cell activation by a truncated variant of Cbl-b related to the rat model of type 1 diabetes mellitus. J. Biochem. 137(6):711-720, 2005.
  3. Liu, S., Chihara, K., and Maeyama, K. The contribution of mast cells to the late-phase of allergic asthma in rats. Inflamm. Res., 54(5), 221-228, 2005

2004

  1. Miah, S. M., Sada, K., Tuazon, P. T., Ling, J., Maeno, K., Kyo, S., Qu, X., Tohyama, Y., Traugh, J. A., and Yamamura, H. Activation of Syk protein-tyrosine kinase in response to osmotic stress requires the interaction with p21-activated protein kinase Pak2/g-PAK. Mol. Cell. Biol. 24(1):71-83, 2004.
  2. Qu, X., Sada, K., Kyo, S., Maeno, K., Miah, S. M., and Yamamura, H. Negative regulation of FceRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Blood 103(5):1779-1786, 2004.
  3. Enoki, E., Sada, K., Qu, X., Kyo, S., Miah, S. M., Hatani, T., Tomoda, A., and Yamamura, H. The phenoxazine derivative Phx-1 suppresses IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells. J. Pharmacol. Sci. 94(3):329-333, 2004.
  4. Miah, S. M., Hatani, T., Qu, X., Yamamura, H., and Sada, K. Point mutations of 3BP2 identified in human inherited disease cherubism result in the loss of function. Genes Cells 9(11):993-1004, 2004.
  5. Gotoh B, Takeuchi K, Komatsu T. Inhibition of the gamma interferon response by a Sendai virus C protein mutant with no STAT1-binding ability. FEBS Lett. 2004 Jun 4;567(2-3):291-6. PubMed PMID: 15178339.
  6. Komatsu T, Takeuchi K, Yokoo J, Gotoh B. C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-beta production. Virology. 2004 Jul 20;325(1):137-48. PubMed PMID: 15231393.

2003

  1. Sada, K. and Yamamura, H. Protein-tyrosine kinases and adaptor proteins in FceRI-mediated signaling in mast cells. Curr. Mol. Med. 3(1):85-94, 2003.
  2. Asahi, M., Tanaka, Y., Izumi, T., Ito, Y., Naiki, H., Kersulyte, D., Tsujikawa, K., Saito, M., Sada, K., Yanagi, S., Fujikawa, A., Noda, M., and Itokawa Y. Helicobacter pylori CagA containing ITAM-like sequences localized to lipid rafts negatively regulates VacA-induced signaling in vivo. Helicobacter 8(1):1-14, 2003.
  3. Maeno, K., Sada, K., Kyo, S., Miah, S. M., Kawauchi-Kamata, K., Qu, X., Shi, Y., and Yamamura, H. Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase. J. Biol. Chem. 278(27):24912-24920, 2003.
  4. Kyo, S., Sada, K., Qu, X., Maeno, K., Miah, S. M., Kawauchi-Kamata, K., and Yamamura, H. Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in FceRI-mediated mast cell activation. Genes Cells 8(10):825-836, 2003.
  5. Gotoh B, Takeuchi K, Komatsu T, Yokoo J. The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling. J Virol. 2003 Mar;77(6):3360-70. PubMed PMID: 12610111; PubMed Central PMCID: PMC149518.
  6. Gotoh B, Komatsu T, Takeuchi K, Yokoo J. The C-terminal half-fragment of the Sendai virus C protein prevents the gamma-activated factor from binding to a gamma-activated sequence site. Virology. 2003 Nov 10;316(1):29-40. PubMed PMID: 14599788.

2002

  1. Takano, T., Sada, K., and Yamamura, H. Role of protein-tyrosine kinase Syk in oxidative stress signaling in B cells. Antioxid. Redox Signal. 4(3):533-540, 2002.
  2. Siraganian, R. P., Zhang, J., Suzuki, K., and Sada, K. The role of protein tyrosine kinase Syk in mast cell signaling. Mol. Immunol. 38(16-18):1229-1233, 2002.
  3. Sada, K., Miah, S. M., Maeno, K., Kyo, S., Qu, X., and Yamamura, H. Regulation of FceRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood 100(6):2138-2144, 2002.
  4. He, J., Takano, T., Ding, J., Gao, S., Noda, C., Sada, K., Yanagi, S., and Yamamura, H. Syk is required for p38 activation and G2/M arrest in B cells exposed to oxidative stress. Antioxid. Redox Signal. 4(3):509-515, 2002.
  5. Gao, S., Takano, T., Sada, K., He, J., Noda, C., Hori-Tamura, N., Tomoda, A., and Yamamura, H. A novel phenoxazine derivative suppresses surface IgM expression in DT40 B cell line. Brit. J. Pharmacol. 137(6):749-755, 2002.
  6. Komatsu T, Takeuchi K, Yokoo J, Gotoh B. Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1. FEBS Lett. 2002 Jan 30;511(1-3):139-44. PubMed PMID: 11821064.
  7. Gotoh B, Komatsu T, Takeuchi K, Yokoo J. Paramyxovirus strategies for evading the interferon response. Rev Med Virol. 2002 Nov-Dec;12(6):337-57. Review. PubMed PMID: 12410527.

2001

  1. Sada, K., Takano, T., Yanagi, S., and Yamamura, H. Structure and function of Syk protein-tyrosine kinase. J. Biochem. 130(2):177-186, 2001.
  2. Sada, K., Zhang, J., and Siraganian, R. P. SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FceRI signaling. Blood 97(5):1352-1359, 2001.
  3. Takeuchi K, Komatsu T, Yokoo J, Kato A, Shioda T, Nagai Y, Gotoh B. Sendai virus C protein physically associates with Stat1. Genes Cells. 2001 Jun;6(6):545-57. PubMed PMID: 11442634.
  4. Gotoh B, Komatsu T, Takeuchi K, Yokoo J. Paramyxovirus accessory proteins as interferon antagonists. Microbiol Immunol. 2001;45(12):787-800. Review. PubMed PMID: 11838896.
  5. Inagaki, N., Chihara, K., Arimura, N., Menager, C., Kawano, Y., Matsuo, N., Nishimura, T., Amano, M., and Kaibuchi, K. CRMP-2 induces axons in cultured hippocampal neurons. Nat. Neurosci., 4(8), 781-782, 2001

2000

  1. Sada, K., Zhang, J., and Siraganian, R. P. Point mutation of a tyrosine in the linker region of Syk results in a gain of function. J. Immunol. 164(1):338-344, 2000.
  2. Komatsu T, Takeuchi K, Yokoo J, Tanaka Y, Gotoh B. Sendai virus blocks alpha interferon signaling to signal transducers and activators of transcription. J Virol. 2000 Mar;74(5):2477-80. PubMed PMID: 10666284; PubMed Central PMCID: PMC111735.
  3. Arimura, N., Inagaki, N., Chihara, K., Menager, C., Nakamura, N., Amano, M., Iwamatsu, A., Goshima, Y., and Kaibuchi, K.
    Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.
    J. Biol. Chem., 275(31), 23973-23980, 2000

1999

  1. Maruo, A., Oishi, I., Sada, K., Nomi, M., Kurosaki, T., Minami, Y., and Yamamura, H. Protein tyrosine kinase lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells. Int. Immunol. 11(9):1371-1380, 1999.
  2. Gotoh B, Takeuchi K, Komatsu T, Yokoo J, Kimura Y, Kurotani A, Kato A, Nagai Y. Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-alpha/beta-mediated responses. FEBS Lett. 1999 Oct 8;459(2):205-10. PubMed PMID: 10518019.
  3. Amano, M., Chihara, K., Nakamura, N., Kaneko, T., Matsuura, Y., and Kaibuchi, K. The COOH terminus of Rho-kinase negatively regulates Rho-kinase activity. J. Biol. Chem., 274(45), 32418-32424, 1999

1998

  1. Rezaul, K., Sada, K., and Yamamura, H. Involvement of reactive oxygen intermediates in lectin-induced protein-tyrosine phosphorylation of Syk in THP-1 cells. Biochem. Biophys. Res. Commun. 246(3):863-867, 1998.
  2. Izawa, I., Amano, M., Chihara, K., Yamamoto, T., and Kaibuchi, K.
    Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.
    Oncogene, 17(22), 2863-2871, 1998
  3. Amano, M., Chihara, K., Nakamura, N., Fukata, Y., Yano, T., Shibata, M., Ikebe, M., and Kaibuchi, K.
    Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase.
    Genes Cells, 3(3), 177-188, 1998

1997

  1. Rezaul, K., Sada, K., Inazu, T., and Yamamura, H. Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. Biochem. Biophys. Res. Commun. 239(1):23-27, 1997.
  2. Sada, K., Minami, Y., and Yamamura, H. Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak. Eur. J. Biochem. 248(3):827-833, 1997.
  3. Chihara, K., Amano, M., Nakamura, N., Yano, T., Shibata, M., Tokui, T., Ichikawa, H., Ikebe, R., Ikebe, M., and Kaibuchi, K.
    Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase.
    J. Biol. Chem., 272(40), 25121-25127, 1997

1996

  1. Maruyama, S., Kurosaki, T., Sada, K., Yamanashi, Y., Yamamoto, T., and Yamamura, H. Physical and functional association of cortactin with Syk in human leukemic cell line K562. J. Biol. Chem. 271(12):6631-6635, 1996.
  2. Nakamura, T., Koyama, M., Yoneyama, A., Higashihara, M., Kawakami, T., Yamamura, H., Sada, K., Okumura, K., and Kurokawa, K. Signal transduction through mkB-cell receptors expressed on pre-B cells is different from that through B-cell receptors on mature B cells. Immunology 88(4):593-599, 1996.

1995

  1. Minami, Y., Nakagawa, Y., Kawahara, A., Miyazaki, T., Sada, K., Yamamura, H., and Taniguchi, T. Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway. Immunity 2(1):89-100, 1995.
  2. Ozaki, Y., Satoh, K., Kuroda, K., Qi, R., Yatomi, Y., Yanagi, S., Sada, K., Yamamura, H., Yanabu, M., Nomura, S., and Kume, S. Anti-CD9 monoclonal antibody activates p72syk in human platelets. J. Biol. Chem. 270(25):15119-15124, 1995.
  3. Asahi, M., Tanaka, Y., Qin, S., Tsubokawa, M., Sada, K., Minami, Y., and Yamamura, H. Cyclic AMP-elevating agents negatively regulate the activation of p72syk in N-formyl-methionyl-leucyl-phenylalanine receptor signaling. Biochem. Biophys. Res. Commun. 212(3):887-893, 1995.
  4. Kurosaki, T., Johnson, S. A., Pao, L., Sada, K., Yamamura, H., and Cambier, J. C. Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J. Exp. Med. 182(6):1815-1823, 1995.

1994

  1. Sada, K., Yanagi, S., and Yamamura, H. Activation of p72syk by thrombin in a cell-free system. Biochem. Biophys. Res. Commun. 200(1):1-7, 1994.
  2. Tsubokawa, M., Yanagi, S., Sada, K., Nakamura, S., Saito, H., and Yamamura, H. CPTK71, a cytosolic protein-tyrosine kinase previously purified from bovine platelets, is identical with p72syk. Biochem. Biophys. Res. Commun. 200(3):1592-1597, 1994.
  3. Qin, S., Inazu, T., Yang, C., Sada, K., Taniguchi, T., and Yamamura, H. Interleukin 2 mediates p72syk activation in peripheral blood lymphocytes. FEBS Lett. 345(2-3):233-236, 1994.
  4. Yanagi, S., Sada, K., Tohyama, Y., Tsubokawa, M., Nagai, K., Yonezawa, K., and Yamamura, H. Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation. Eur. J. Biochem. 224(2):329-333, 1994.
  5. Wang, X., Sada, K., Yanagi, S., Yang, C., Rezaul, K., and Yamamura, H. Intracellular calcium dependent activation of p72syk in platelets. J. Biochem. 116(4):858-861, 1994.
  6. Fujii, C., Yanagi, S., Sada, K., Nagai, K., Taniguchi, T., and Yamamura, H. Involvement of protein-tyrosine kinase p72syk in collagen-induced signal transduction in platelets. Eur. J. Biochem. 226(1):243-248, 1994.
  7. Rezaul, K., Yanagi, S., Sada, K., Taniguchi, T., and Yamamura, H. Protein-tyrosine kinase p72syk is activated by platelet activating factor in platelets. Thromb. Haemost. 72(6):937-941, 1994.
  8. Tohyama, Y., Yanagi, S., Sada, K., and Yamamura, H. Translocation of p72syk to the cytoskeleton in thrombin-stimulated platelets. J. Biol. Chem. 269(52):32796-32799, 1994.

1993

  1. Takeuchi, N., Hashimoto, E., Nakamura, T., Takeuchi, F., Sada, K., and Yamamura, H. Possible role of Na+ influx in phorbol ester-induced down-regulation of protein kinase C in HL60 cells. FEBS Lett. 328(3):280-284, 1993.

1988

  1. Sakai, K., Nakamura, S., Sada, K., Kobayashi, T., Uno, H., and Yamamura, H. Characterization of partially purified cytosolic protein-tyrosine kinase from porcine spleen. Biochem. Biophys. Res. Commun. 152(3):1123-1130, 1988.
  2. Sakai, K., Sada, K., Tanaka, Y., Kobayashi, T., Nakamura, S., and Yamamura, H. Regulation of cytosolic protein-tyrosine kinase from porcine spleen by polyamines and negative-charged polysaccharides. Biochem. Biophys. Res. Commun. 154(3):883-889, 1988.

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