福井大学医学部

腎臓病態内科学(臨床検査医学)

研究業績

2011年以降の業績を掲載しています。

学術論文

2018

  1. Kobayashi M, Mikami D, Uwada J, Yazawa T, Kamiyama K, Kimura H, Taniguchi T, Iwano M. A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells. Oncotarget. 2018 Jul 31;9(59):31342-31354.
  2. Oshima M, Toyama T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki S, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Hara A, Makino H, Wada T; Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan.Estimated glomerular filtration rate decline and risk of end-stage renal
    disease in type 2 diabetes. PLoS One. 2018 Aug 2;13(8):e0201535. doi: 10.1371/journal.pone.0201535. eCollection 2018.
  3. Kubota W, Honda M, Okada H, Hattori M, Iwano M, Akioka Y, Ashida A, Kawasaki Y, Kiyomoto H, Sako M, Terada Y, Hirano D, Fujieda M, Fujimoto S, Masaki T, Ito S, Uemura O, Gotoh Y, Komatsu Y, Nishi S, Maru M, Narita I, Maruyama S. A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood.
    Clin Exp Nephrol. 2018 Aug;22(4):743-751.
  4. Kagawa T, Kozai M, Masuda M, Harada N, Nakahashi O, Tajiri M, Yoshikawa R, Nakao M, Takei Y, Iwano M, Takeda E, Taketani Y, Yamamoto H. Sterol regulatory element binding protein 1 trans-activates 25-hydroxy
    vitamin D3 24-hydroxylase gene expression in renal proximal tubular cells. Biochem Biophys Res Commun. 2018 Jun 2;500(2):275-282.
  5. Yoshikawa R, Yamamoto H, Nakahashi O, Kagawa T, Tajiri M, Nakao M, Fukuda S, Arai H, Masuda M, Iwano M, Takeda E, Taketani Y. The age-related changes of dietary phosphate responsiveness in plasma
    1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice. J Clin Biochem Nutr. 2018 Jan;62(1):68-74.
  6. Wada T, Muso E, Maruyama S, Hara A, Furuichi K, Yoshimura K, Miyazaki M, Sato E, Abe M, Shibagaki Y, Narita I, Yokoyama H, Mori N, Yuzawa Y, Matsubara T, Tsukamoto T, Wada J, Ito T, Masutani K, Tsuruya K, Fujimoto S, Tsuda A, Suzuki H, Kasuno K, Terada Y, Nakata T, Iino N, Kobayashi S. Rationale and study design of a clinical trial to assess the effects of LDL apheresis on proteinuria in diabetic patients with severe proteinuria and dyslipidemia. Clin Exp Nephrol. 2018 Jun;22(3):591-596.

2017

  1. Takahashi Naoki, Saeki Takako, Komatsuda Atsushi, Munemura Chishio, Fukui Takeaki, Imai Naofumi, Homma Noriyuki, Hatta Tsuguru, Samejima Ken-Ichi, Fujimoto Takashi, Omori Hiroki, Ito Yumi, Nishikawa Yudai, Kobayashi Mamiko, Morikawa Yukie, Fukushima Sachiko, Yokoi Seiji, Mikami Daisuke, Kasuno Kenji, Kimura Hideki, Nemoto Tomoyuki, Nakamoto Yasunari, Sada Kiyonao, Sugai Manabu, Naiki Hironobu, Yoshida Haruyoshi, Narita Ichiei, Saito Yoshihiko, Iwano Masayuki: Tubulointerstitial Nephritis with IgM-Positive Plasma Cells., Journal of the American Society of Nephrology : JASN, 2017
  2. Kobayashi Mamiko, Mikami Daisuke, Kimura Hideki, Kamiyama Kazuko, Morikawa Yukie, Yokoi Seiji, Kasuno Kenji, Takahashi Naoki, Taniguchi Takanobu, Iwano Masayuki: Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells., Biochemical and biophysical research communications, 486(2), 499-505, 2017
  3. Noriki S, Kinoshita K, Inai K, Sakai T, Kimura H, Yamauchi T, Iwano M, Naiki H.
  4. Newly recognized cerebral infarctions on postmortem imaging: a report of three cases with systemic infectious disease. BMC Med Imaging. 2017 Jan 10;17(1):4.
  5. Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Sasatomi Y, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; Refractory Nephrotic Syndrome Study Group. Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome.
    Clin Exp Nephrol. 2017 Dec;21(6):961-970.

2016

  1. Shimada A, Kimura H, Oida K, Kanehara H, Bando Y, Sakamoto S, Wakasugi T, Saga T, Ito Y, Kamiyama K, Mikami D, Iwano M, Hirano T, Yoshida H.
    Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association.
    Lipids Health Dis. 17;15:57. 2016
  2. Hattori M, Iwano M, Sako M, Honda M, Okada H, Akioka Y, Ashida A, Kawasaki Y, Kiyomoto H, Terada Y, Hirano D, Fujieda M, Fujimoto S, Masaki T, Maruyama S, Mastuo S.
    Transition of adolescent and young adult patients with childhood-onset chronic kidney disease from pediatric to adult renal services: a nationwide survey in Japan.
    Clin Exp Nephrol.20(6):918-925. 2016
  3. Morimoto K, Nakatani K, Asai O, Mondori K, Tomiwa K, Mondori T, Nakagawa Y, Iwano M, Shiiki H. A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome complicated by IgA nephropathy with nephrotic syndrome. CEN Case Rep. 2016 May;5(1):26-30.

2015

  1. Matsui M, Uemura S, Takeda Y, Samejima KI, Matsumoto T, Hasegawa A, Tsushima H, Hoshino E, Ueda T, Morimoto K, Okamoto K, Okada S, Onoue K, Okayama S, Kawata H, Kawakami R, Maruyama N, Akai Y, Iwano M, Shiiki H, Saito Y; NARA-CKD Investigators.  Placental Growth Factor as a Predictor of Cardiovascular Events in Patients with CKD from the NARA-CKD Study.  J Am Soc Nephrol. 2015 Mar 18. pii: ASN.2014080772.
  2. Kimura N, Kimura H, Takahashi N, Hamada T, Maegawa H, Mori M, Imamura Y, Kusaka Y, Yoshida H, Iwano M.  Renal resistive index correlates with peritubular capillary loss and arteriosclerosis in biopsy tissues from patients with chronic kidney disease.  Clin Exp Nephrol. 2015 Jun 17.
  3. Sakuraba H, Tsukimura T, Tanaka T, Togawa T, Takahashi N, Mikami D, Wakai S, Akai Y.  Clinical and biochemical investigation of male patients exhibiting membranous cytoplasmic bodies in biopsied kidney tissues; a pitfall in diagnosis of Fabry disease.  J Nephropathol. 2015 Jul;4(3):91-6. doi: 10.12860/jnp.2015.17. Epub 2015 Jul 1.

2014

  1. Matsui M, Takeda Y, Uemura S, Matsumoto T, Seno A, Onoue K, Tsushima H, Morimoto K, Soeda T, Okayama S, Somekawa S, Samejima K, Kawata H, Kawakami R, Nakatani K, Iwano M, Saito Y. Suppressed soluble Fms-like tyrosine kinase-1 production aggravates atherosclerosis in chronic kidney disease. Kidney Int. 2014 Feb;85(2):393-403.
  2. Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki S, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes. Clin Exp Nephrol. 2014 Aug;18(4):613-20.
  3. Mikami D, Kimura H, Kamiyama K, Torii K, Kasuno K, Takahashi N, Yoshida H, Iwano M. Telmisartan activates endogenous peroxisome proliferator-activated receptor-δ and may have anti-fibrotic effects in human mesangial cells. Hypertens Res. 2014 May;37(5):422-31.
  4. Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Shuto H, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; Refractory Nephrotic Syndrome Study Group. Significance of combined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial. Clin Exp Nephrol. 2014 Oct;18(5):784-94.
  5. Nakatani K, Asai O, Sakan H, Yoshimoto S, Terada M, Nose M, Iwano M, Konishi N. Association between E-selectin expression and histopathological modification of glomerular lesions by non-nephritogenic IgM antibodies in experimental lupus nephritis.
    Mod Rheumatol. 2014 Sep;24(5):808-15.
  6. Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y. Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism. PLoS One. 2014 Jan 23;9(1):e86301.
  7. Ikeda S, Yamamoto H, Masuda M, Takei Y, Nakahashi O, Kozai M, Tanaka S, Nakao M, Taketani Y, Segawa H, Iwano M, Miyamoto K, Takeda E. Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation. Am J Physiol Renal Physiol. 2014 Apr 1;306(7):F744-50.
  8. Nakahashi O, Yamamoto H, Tanaka S, Kozai M, Takei Y, Masuda M, Kaneko I, Taketani Y, Iwano M, Miyamoto K, Takeda E. Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice. J Clin Biochem Nutr. 2014 Mar;54(2):102-8.
  9. Takahashi N, Yokoi S, Kasuno K, Kogami A, Tsukimura T, Togawa T, Saito S, Ohno K, Hara M, Kurosawa H, Hirayama Y, Kurose T, Yokoyama Y, Mikami D, Kimura H, Naiki H, Sakuraba H, Iwano M. A heterozygous female with Fabry disease due to a novel alpha-galactosidase A mutation exhibits a unique synaptopodin distribution in vacuolated podocytes. Clin Nephrol. 2014 Oct 8.
  10. Kasuno K, Shirakawa K, Yoshida H, Mori K, Kimura H, Takahashi N, Nobukawa Y, Shigemi K, Tanabe S, Yamada N, Koshiji T, Nogaki F, Kusano H, Ono T, Uno K, Nakamura H, Yodoi J, Muso E, Iwano M. Renal redox dysregulation in AKI: application for oxidative stress marker of AKI. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1342-51.
  11. Kimura H, Mikami D, Kamiyama K, Sugimoto H, Kasuno K, Takahashi N, Yoshida H, Iwano M. Telmisartan, a possible PPAR-δ agonist, reduces TNF-α-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells. Biochem Biophys Res Commun. 2014 Nov 14;454(2):320-7
  12. Moriya T, Suzuki Y, Inomata S, Iwano M, Kanauchi M, Haneda M.  Renal histological heterogeneity and functional progress in normoalbuminuric and microalbuminuric Japanese patients with type 2 diabetes.  BMJ Open Diabetes Res Care. 2014 Aug 8;2(1):e000029

2013

  1. Furuichi K, Shimizu M, Toyama T, Koya D, Koshino Y, Abe H, Mori K, Satoh H, Imanishi M, Iwano M, Yamauchi H, Kusano E, Fujimoto S, Suzuki Y, Okuda S, Kitagawa K, Iwata Y, Kaneko S, Nishi S, Yokoyama H, Ueda Y, Haneda M, Makino H, Wada T; Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan.  Japan Diabetic Nephropathy Cohort Study: study design, methods, and implementation. Clin Exp Nephrol. 2013 Dec;17(6):819-26.
  2. Harada K, Akai Y, Sumida K, Yoshikawa M, Takahashi H, Yamaguchi Y, Kubo A, Iwano M, Saito Y.  Significance of renal biopsy in patients with presumed diabetic nephropathy.  J Diabetes Investig. 2013 Jan 29;4(1):88-93.

2012

  1. Hida Y, Hisada K, Shimada A, Yamashita M, Kimura H, Yoshida H, Iwasaki H, Iwano M.
    Rapid detection of the Mycobacterium tuberculosis complex by use of quenching probe PCR (geneCube).  J Clin Microbiol. 2012 Nov;50(11):3604-8.
  2. Takahashi N, Kimura H, Mizuno S, Hara M, Hirayama Y, Kurosawa H, Tsutaya S, Yasujima M, Yokoi S, Mikami D, Kasuno K, Naiki H, Iwano M, Yoshida H.  Clin Exp Nephrol. 2012 Jun;16(3):495-500.
  3. Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y.  Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion.  Kidney Int. 2012 Mar;81(6):539-47.
  4. Samejima K, Nakatani K, Suzuki D, Asai O, Sakan H, Yoshimoto S, Yamaguchi Y, Matsui M, Akai Y, Toyoda M, Iwano M, Saito Y.  Clinical significance of fibroblast-specific protein-1 expression on podocytes in patients with focal segmental glomerulosclerosis.  Nephron Clin Pract. 2012;120(1):c1-7.
  5. Iwano M, Yamaguchi Y, Iwamoto T, Nakatani K, Matsui M, Kubo A, Akai Y, Mori T, Saito Y.  Urinary FSP1 is a biomarker of crescentic GN.  J Am Soc Nephrol. 2012 Feb;23(2):209-14.

2011

  1. Kubo A, Stull R, Iwano M et al.
    Pdx1 and Ngn3 Overexpression Enhances Pancreatic Differentiation of Mouse ES Cell-Derived Endoderm Population.
    PLoS One 2011, 6:e24058, Epub, 2011
  2. Kasuno K, Kimura H, Takahashi N, Mikami D, Yokoyama Y, Nobukawa Y, Shigemi K, Yoshida H.
    Clinical application of urinary redox regulating protein, thioredoxin.
    Rinsho Byori. 2011 Feb;59(2):189-95.
  3. Kimura H, Miyazaki R, Imura T, Masunaga S, Shimada A, Mikami D, Kasuno K, Takahashi N, Hirano T, Yoshida H.
    Smaller low-density lipoprotein size as a possible risk factor for the prevalence of coronary artery diseases in haemodialysis patients: associations of cholesteryl ester transfer protein and the hepatic lipase gene polymorphism with low-density lipoprotein size.
    Nephrology (Carlton). 2011 Aug;16(6):558-66.
  4. Kimura H, Li X, Torii K, Okada T, Kamiyama K, Mikami D, Kasuno K, Takahashi N, Yoshida H.
    Glucocorticoid enhances hypoxia- and/or transforming growth factor-β-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells.
    Clin Exp Nephrol. 2011 Feb;15(1):34-40. Epub 2010 Nov 3.
  5. Samejima K, Nakatani K, Iwano M et al.
    Clinical significance of fibroblast-specific protein 1 expression on podocytes in patients with focal segmental glomerulosclerosis Nephron Clinical Practice, in press
  6. Iwano M, Yamaguchi Y et al.
    Urinary FSP1 Is a Novel Biomarker for the Diagnosis of Crescentic Glomerulonephritis J Am Soc Nephrol, in press
  7. Asai O, Nakatani K, Iwano M et al.
    Decreased renal α-Klotho expression and urinary calcium loss in early diabetic nephropathy in humans and mice Kidney Int, in press

腎臓病態内科学(臨床検査医学)研究室

TEL
0776-61-3111
FAX
0776-61-8120
メール
miwano@u-fukui.ac.jp