著書・総説等
2017
- 菅井 学: 抗体の機能的差異を生み出す分子機構の解析, 上原記念生命科学財団研究報告集(CD-ROM), (31), ROMBUNNo.39, 201712
2016
- Chronic inflammation :Roles of the Epithelial Autophagy in the Intestinal Mucosal Barrier Aoki K. and Sugai M.603-616(2016)
- 菅井 学: ミトコンドリア機能と活性化B細胞分化, 医学の歩み, 253(13), 1327-1328, 2016
2012
- 菅井学、南部由希子、清水章 『制御性T細胞と大腸炎関連発癌』 編集 吉川敏一、浅香正博、千葉勉ら 『G.I. Research』 先端化学社
Vol20, 466-471ページ(2012) - 菅井学、渡邊翔、南部由希子、林達成、清水章 『IgAへのクラススイッチと転写因子(Runx2/3)』 編集 矢田純一、羅智靖 『臨床免疫・アレルギー科』 化学評論社
Vol57, 484-493ページ(2012)
2011
- Sugai, M. #, Watanabe, K., Nambu, Y., Hayashi, T. and Shimizu, A.
#S.M. corresponding author
Functions of Runx in IgA class switch recombination.
J. Cellular Biochemistry, (2011) 112; 409-414. 21268061
学術論文等
2021
- A. Murashima-Suginami, H. Kiso, Y. Tokita, E. Mihara, Y. Nambu, R. Uozumi, Y. Tabata, K. Bessho, J. Takagi, M. Sugai, K. Takahashi :Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling :Science Advances(2021)7,7,eabf1798
2020
- Akira Utsunomiya,Takenao Chino,Natsuko Utsunomiya,Vu HuyLong,Atsushi Tokuriki,Tatsuro Naganuma,Makoto Arita,Kiyoshi Higashi,Kouchi Saito,Noriyuki Suzuki,Ayako Ohara,Manabu Sugai,Daisuke Tsuruta,Noritaka Oyama,Minoru Hasegawa:Homeostatic unction of Dermoskine in the Skin Barrier and Inlammation:J Invest Dermatol.(2019),140,4,838-849,
- Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Manabu Sugai, Yasuhiko Tabata, Kazuhisa Bessho:Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy :INFLAMMATION AND REGENERATION(2020)40,1,
2019
- H.Kiso,K.Takahashi,S.Mishima,A.Murashima-Suginami,A.Kakeno,T.Tamazaki,K.Asai,Y.Tokita,R,Uozumi,M.Sugai,H.Harada,B.Huang,M.MacDougall,K.Bessho:Third Dentition Is the Main Cause o Premolar Supernumerary Tooth ormation,Journal of Dental Reserch(2019),98,9,968-974,
- Akira Utsunomiya,Takenao Chino,Natsuko Utsunomiya,Vu HuyLong,Atsushi Tokuriki,Tatsuro Naganuma,Makoto Arita,Kiyoshi Higashi,Kouchi Saito,Noriyuki Suzuki,Ayako Ohara,Manabu Sugai,Daisuke Tsuruta,Noritaka Oyama,Minoru Hasegawa:Homeostatic unction of Dermoskine in the Skin Barrier and Inlammation:J Invest Dermatol.(2019),140,4,838-849,
- 菅井 学、南部 由希子: 免疫とミトコンドリア機能, 生命の科学, 70, 114-119, 2019
- Katsuhiko Itoh, Gen Kondoh, Hitoshi Miyachi, Manabu Sugai, Yoshiyuki Kaneko, Satsuki Kitano, Hitomi Watanabe, Ryota Maeda, Akihiro Imura, Yu Liu, Chizuru Ito, Shigeyoshi Itohara, Kiyotaka Toshimori, Jun Fujita:Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo:Science Signaling(2019),12,574,
- Akari Nitta, Kazuya Hori, Isei Tanida, Ayumi Igarashi, Yasuyo Deyama, Takashi Ueno, Eiki Kominami, Manabu Sugai, Koji Aoki:Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S:Biochemical and Biophysical Research Communications(2019),508,2.521,
2018
- Yamazaki Y, Nambu Y, Ohmae M, Sugai M, Kimura S: Immune responses against Lewis Y tumor-associated carbohydrate antigendisplayed densely on self-assembling nanocarriers., Organic & biomolecular chemistry, (2018)16(43), 8095-8105,
- Isobe Y, Takahashi K, Kiso H, Nakao K, Ikeno M, Koyama N, Sugai M, Shimizu A, Haga H, Bessho K: Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia., Archives of oral biology(2018), 93, 133-140,
- Nitta A., Hori K., Tanida I., Igarashi A., Deyama Y., Ueno T., Kominami E., Sugai M. and Aoki A: Blocking LC3 lipidation andATG12 conjugation reactions by ATG7 mutant protein containing C572S, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS(2018),508(2), 521-526,
- Itoh K., Kondoh G., Miyachi H., Sugai M., Kaneko Y., Kitano S., Watanabe H., Maeda R., Imura A., Lin Y., Ito C., Itohara S.,Toshimori K. and Fujita J: Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo,Science Signaling(2018), 12(574), eaao7232,
2017
- Tubulointerstitial Nephritis with IgM-Positive Plasma Cells.N.Takahashi,T.Saeki,A.Komatsuda,C.Munemura,T.Fukui,N.Imai,N.Homma,T.Hatta,KI.Samejima, T.Fujimoto,H.Omori,Y.Ito,Y.Nishikawa,M.Kobayashi,Y.Morikawa,S.Fukushima,S.Yokoi,D.Mikami,K.Kasuno,H.Kimura,T.Nemoto,Y.Nakamoto,K.Sada,M.Sugai,H.Naiki,H.Yoshida,I.Narita,Y Saito,M.Iwano :Journal of the American Society of Nephrology (2017)28:12:3688~3698 K.Mori,H.Nakamura,H.Miyachi,K.Tamada,M.Sugai,T.Takumi,Y.Yokota
- Id2 determines intestinal identity through repression of the foregut transcription factor,Irx5Molecular and cellular biology(2017)R.Ebina-Shibuya,M.Matsumoto,M.Kuwahara,KJ.Jang,M.Sugai,Y.Ito,R.Funayama,K.Nakayama,Y. Sato,N.Ishii,Y.Okamura,K.Kinoshita,K.Kometani,T Kurosaki,A.Muto,M.Ichinose,M.Yamashita,K. Igarashi
- Inflammatory responses induce an identity crisis of alveolar macrophages leading to pulmonary alveolar proteinosis.J. Biological Chemistry(2017):292:44:18098~18112K.Saito,K.Takahashi,B.Huang,M.Asahara,H.Kiso,Y.Togo,H.Tsukamoto,S.Mishima, M.Nagata,M.Iida,Y.Tokita,M.Asai,A.Shimizu,T.Komori,H.Harada,M.MacDougall,M.Sugai,K.Bessho
- Loss of Stemness,EMT,and Supernumerary Tooth Formation in Cebpb-/-Runx2+/-Murine lncisors Scientific reports (2018):8:1:5169
2016
- Y.Togo,K.Takahashi,K.Saito,H.KIso,H.Tsukamoto,B.Huang,M.Yanagita,M.Sugai, H.Komori,A.Shimizu,M.MacDougall,K.BesshAntagonistic Functions of USAG-1 and RUNX2 during Tooh Development.PLoS One(2016)12;11
- O.Takeuchi,A.Konno,H.Takakura,M.Hattori,T.Ozawa: Bioluminescent Indicator for Highly Sensitive Analysis of Estrogenic
Activity in a Cell-Based Format, Bioconjugate Chemistry, 27(11), 2689-2694, 201611, DOI: 10.1021-acs.bioconjchem.6b00466, - Saito K., Takahashi K., Asahara M., Kiso H., Togo Y., Tsukamoto H., Huang B., Sugai M., Shimizu A., Motokawa M., Slavkin HC.,
Bessho K: Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis., BMC Dev Biol, 13;16:14, 2016 - 斎藤 和幸,高橋 克,喜早 ほのか,東郷 由弥子,三島 清香,GAMEL Dahy Ahamed Khamed Khaled,AGHAZADEH Marziyeh,菅井 学,永田 昌
毅,原田 英光,別所 和久: マウス切歯体性幹細胞を用いた歯の再生モデル, 再生医療, 16(358), 201702
2015
- Jang, K J., Mano, H., Aoki, K. Hayashi, T., Muto A., Nambu, Y., Takahashi, K., Itoh, K., Taketani, S., Nutt, SL., Igarashi, K., Shimizu, A. and Sugai, M.
Mitochondrial function provides instructive signals for activation-induced B-cell fates
Nat. Commns. (2015); 6: Article number: 6750: DOI: 10.1038/ncomms7750 - Biyajima, K., Kakizaki, F., Shen, X., Mori, K., Sugai, M., Taketo, MM. and Yokota, Y.
Id2 deletion attenuates Apc-deficient ileal tumor formation
Biol. Open (2015); 104: DOI: 10.1242/bio.012252 - Kim, C J., Hara, E., Shimizu, A., Sugai, M., and Kimura, S.
Activation of B1a Cells in Peritoneal Cavity by T Cell-Independent Antigen Expressed on Polymeric Micelle
J. Pharmaceutical Science (2015); 104: 1839-1847 - Huang, B., Takahashi, K., Goto, T., Kiso, H., Sugai, M., Shimizu, A. Kosugi, S. and Bessho, K.
ANKH Polymorphisms and Clicking of the Temporomandibular Joint in Dental Residents.
J. Maxillofac. Oral Surg. (2015); 14: 247-251
2014
- Kiso, H., Takahashi, K., Saito, K., Togo, Y., Tsukamoto, H., Huang, B., Sugai, M., Shimizu, A., Tabata, Y., Economides, AN., Slavkin, HC. And Bessho, K.
Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supermumerary Organ Formations.
PLoS ONE (2014); DOI: 10.1371/journal.pone.009638 - Huang, B., Takahashi, K., Jennings, EA., Pumtangon, P., Kiso, H., Togo, Y., Saito, K., Sugai, M., Akira, S., Shimizu, A. and Bessho, K.
Prospective signs of cleidocranial dysplasia in Cebpb deficiency.
J. Biomed. Sci.2014 May 13;21:44. doi: 10.1186/1423-0127-21-44. - Naito-Matsui.Y., Takada, S., Kano, Y., Iyoda, T., Sugai, M., Shimizu, A., Inaba, K., Nitschke, L., Tsubata, T., Oka, S., Kozutsumi, Y. and Takematsu, H.
Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells.
J. Biol. Chem. (2014); 289: 1564-1579.
2013
- Hara, E., Makino, A., Kurihara, K., Sugai, M., Shimizu, A., Hara, I., Ozeki, E., Kimura, S.
Evasion from accelerated blood clearance of nanocarrier named as “Lactosome” induced by excessive administration of Lactosome.
Biochim Biophys Acta (2013); 1830: 4046-4052. 23545239 - Adachi AA, Fujioka A, Nagano M, Masumoto KH, Takumi T, Yoshimura T, Ebihara S, Mori K, Yokota Y, Shigeyoshi Y. Helix-loop-helix Protein Id2 Stabilizes Mammalian Circadian Oscillation Under Constant Light Conditions.Zoolog Sci;30:1011-1018.2013
- H.Kurooka, M.Sugai, K.Mori, Y.Yokota. The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues.Biochem. Biophys. Res. Commun; 433 :579-585.2013
2012
- Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Akira, S., Shimizu, A., Bessho, K.
Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process.
Oral Disease (2012); 19: 144-150. 22849712 - Nambu, Y., Hayashi, T., Jang, K.J., Aoki, K., Mano, H., Nakano, K., Osato, M., Takahashi, K., Itoh, K., Teramukai, S., Komori, T., Fujita, J., Ito, Y., Shimizu, A. and Sugai, M. #
#S.M. corresponding author
In situ differentiation of CD8aaT cells from CD4T cells in the peripheral lymphoid tissues
Sci Rep. (2012); 2: 642. 22962636 - Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, H., Takemoto, M., Hayashi, T., Sugai, M. Nakamura, T., Yokota, Y., Shimizu, A., Slavkin, H. and Bessho, K.
Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis.
Bone, (2012); 50: 69-78. 21985998 - Yu, S, Zhou, X, Steinke, F.C, Liu, C, Chen, S.-C, Zagorodna, O, Jing, X, Y.Yokota, Meyerholz, D.K, Mullighan, C.J, Knudson, C.M, Zhao, D.-M, Xue, H.-H. The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity;37:813-826.2012
- Seré, K, Baek, J.-H, Ober-Blöbaum, J, Müller-Newen, G, Tacke, F, Y.Yokota, Zenke, M, Hieronymus,T. Two distinct types of Langerhans cells populate the skin during steady state and inflammation.Immunity;37;905-916.2012
- Kim, D.Y, Fukuyama, S, Nagatake, T, Takamura, K, Kong, I.G, Y.Yokota, Lee, C.H, Kiyono, H,Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model.Allergy;67:502-509.2012
- Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, T., Takemoto, M., Sugai, M., Nakamura, T., Yokota, Y., Shimizu, A., Slavkin, H. and Bessho, K.: Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis. Bone, 50: 69-78, 2012.
- Oh, J., Lee, M.S., Yeon, J.T., Choi, S.W., Kim, H.S., Shim, H., Lee, S.Y., Youn, B.S., Yokota, Y., Kim, J.H. and Kwak, H.B.: Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-fos and Id protein expression. J. Cell. Physiol., 227: 1851-1860, 2012
- Kurooka, H., Nakahiro, T., Mori, K., Sano, K. and Yokota, Y.: BMP signaling is responsible for serum-induced Id2 expression. Biochem. Biophys. Res. Com., Biochem. Biophys. Res. Commun.,420:281-287. 2012.
2011
- Ishikawa, C., Sawada, S., Nakachi, S., Senba, M., Sugai, M. and Mori, N.
Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis.
Carcinogenesis (2011); 32: 110-119. 20974684 - Huang, B., Takahashi, K., Sakata, T., Kiso, H., Sugai, M., Fujimura, K., Shimizu, A., Kosugi, S., Sato, T. and Bessho, K.
Increased risk of TMJ closed lock: a study of ANKH polymorphisms.
PLOS ONE, (2011); 6: e25503. 22003394 - Sugai, M. #,$, Aoki, K. $, Osato, M., Nambu, Y., Ito, K., Taketo, M. M., and Shimizu, A. #
#S.M. , S.A. corresponding author, $ S.M. and A.K. contributed equally
Runx3 Is Required for Full Activation of Regulatory T Cells To Prevent Colitis-Associated Tumor Formation.
J. Immunol. (2011); 186: 6515-6520. 21515792 - Jongbloed, M.R., Vicente-Steijn, R., Douglas, Y.L., Wisse, L.J., Mori, K., Yokota, Y., Bartelings, M.M., Schalij, M.J., Mahtab, E.A., Poelmann, R.E., Gittenberger-De Groot, A.C.: Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Dev. Dyn., 240: 2561-2577, 2011.
- Egusa, H., Doi, M., Saeki, M., Fukuyasu, S., Akashi, Y., Yokota, Y., Yatani, H. and Kamisaki, Y.: The small-molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells. Bone, 49: 264-274, 2011.
- Kim, D.Y., Sato, A., Fukuyama, S., Sagara, H., Nagatake, T., Kong, I.G., Goda, K., Nochi, T., Kunisawa, J., Sato, S., Yokota, Y., Lee, C.H. and Kiyono, H.: The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J. Immunol., 186: 4253-4262, 2011.
2010
- Watanabe, K., Sugai, M. #, Nambu, Y., Osato, M., Hayashi, T. , Kawaguchi, M. , Komori, T. , Ito, Y., Shimizu, A. #
#S.M. and S.A. corresponding author
Requirement for Runx proteins in IgA class switching acting downstream of TGF-β1 and retinoic acid signaling.
J. Immunol. (2010); 184: 2785-2792. 20142360 - Identification of BMP-responsive elements in the mouse Id2 gene
T.Nakahiro, H.Kurooka, K.Mori, K.Sano, Y.Yokota
Biochem. Biophys. Res. Commun. 2010.08 - Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association
with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia
cell line.
N.Hosono, S.Kishi, S.Iho, Y.Urasaki, A.Yoshida, H.Kurooka, Y.Yokota, T.Ueda
Cancer Sci. 2010.03
学会発表等
2019
- 菅井 学: 免疫とミトコンドリア, 19-1バイオ・高分子研究会, あわら市, 20190927
2017
- 菅井 学: Mitochondrial function in cell fate determination of activated B cells., 2017年度生命科学系学会合同年次大会, 神戸,201712
2016
- 服部 満: ルシフェラーゼ再構成を基盤としたGPCRシグナルの発光定量検出法, 日本薬学会第137年会 SENDAI 2017, 仙台, 20170325
- 服部 満,河村 玄気,小嶋 良輔,神谷 真子,浦野 泰照,小澤 岳昌,: 共焦点発行イメージングを利用した生細胞観察法の開発, 第39回日
本分子生物学会年会, 横浜市, 20161130 - 林 達成、南部 由希子、眞野 浩人、ジャン キョンジン、東雄 二郎、クリスティン ヴァーシェーレン、ダニー ハイレボーエック、清水
章、菅井 学: Transcription factor Sip1 functions to prevent autoimmunity in the BCR checkpoint of immature B cell stage, 第89
回日本生化学会大会, 仙台国際センター(宮城県 仙台市), 20160926 - 服部 満: 化学発光イメージングワークショップ, 第2回化学発光イメージングワークショップ, 大阪大学産業科学研究所, 20170208
2015
- 菅井 学: ミトコンドリア機能による活性化B細胞運命決定機構, 第39回日本鉄バイオサイエンス学会学術集会, 岡山コンベンションセンター
(岡山県 岡山市), 20150829 - Hayashi T., Nambu Y., Jang KJ., Mano H., Higashi Y., Verschueren K., Huylebroeck D., Shimizu A. Sugai M.: The role of
transcription factor Sip1 for the repression of Rag genes and its synergistic effect with CD19 on autoimmunity, 日本免疫学会学
術集会, 札幌コンベンションセンター(北海道 札幌), 20151119 - 林達成, 南部由希子, 眞野浩人, ジャンキョンジン, 東雄二郎, クリスティンヴァーシェーレン, ダニーハイレボーエック, 清水章, 菅井学:
転写因子Sip1によるIL-7シグナルおよび免疫グロブリン遺伝子組換えの制御, 第88回日本生化学会大会 合同大会, 20151202 - Jang, K J., Mano, H., Aoki, K. Hayashi, T., Muto A., Nambu, Y., Takahashi, K., Itoh, K., Taketani, S., Nutt, SL., Igarashi, K.,
Shimizu, A. and Sugai, M.: Mitochondrial function provides instructive signals for activation-induced B-cell fates., 日本免疫学
会学術集会, 札幌コンベンションセンター(北海道 札幌), 20151119 - Tatsunari Hayashi: Regulation of IL-7 signaling and immunoglobulin gene recombination by the transcription factor Sip1, 第38
回日本分子生物学会, 20151201
2014
- Sugai M, Kyoung-Jin Jang , Kazuhiko Igarashi and Akira Shimizu : Mitochondrial function regulates heme oxygenase-1 expression through modulating ability of heme synthesis 8th International Conference on Heme Oxygeneses, BioIron & Oxidative Stress, Sydney, 2014. (Oral presentation)
- Sugai M, Kyoung-Jin Jang : B cell-fate determination by mitochondrial ROS via inhibition of heme synthesis 第87回日本生化学会大会 シンポジウム、2014 (口頭発表)
2013
- Irx3/5トランスジェニックマウスを用いた異所性胃上皮形成機構の解析 森 健太郎, 宮地 均, 横田 義史 第36回日本分子生物学会年会
- ヒ素による転写抑制因子Id3の核外輸送 黒岡 尚徳, 菅井 学, 森 健太郎, 横田 義史 第86回日本生化学会大会
2012
- Id2の欠損はApc遺伝子変異マウスの回腸腫瘍の形成を抑制する 美谷島 杏子, しん 暁東, 森 健太郎, 武藤 誠, 横田 義史 第35回日本分子生物学会年会
- 転写調節因子Id2による消化管上皮細胞の運命決定機構 森 健太郎, 中村 ハルミ, 宮地 均, 玉田 紘太, Hui Chi-Chung, 内匠 透, 横田 義史 第35回日本分子生物学会年会
- 血清が誘導するId2の発現と筋芽細胞の分化阻害におけるBMPシグナルの役割 黒岡 尚徳, 横田 義史 第35回日本分子生物学会年会
2011
- 転写調節因子Id2による消化管上皮細胞の運命決定機構 森 健太郎, 中村 ハルミ, 玉田 紘太, 内匠 透, 横田 義史 第44回日本発生生物学会年会
- 転写調節因子Id2による消化管上皮細胞の運命決定機構 森 健太郎, 中村 ハルミ, 横田 義史 日本生化学会北陸支部第29回大会
- 転写抑制因子Id2による消化管上皮細胞の運命決定機構 森 健太郎, 中村 ハルミ, 宮地 均, 玉田 紘太, Chi-Chung Hui, 内匠 透, 横田 義史 第34回日本分子生物学会年会
2010
- 酸化ストレスにより形成されるHLHタンパク質の分子間ジスルフィド結合
黒岡 尚徳, 横田 義史
第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
2010.12 神戸