福井大学医学部

ゲノム科学・微生物学

研究業績

各教員のすべての業績はJST Researchmapを参照ください。リンク先はこのページの最後に示します。

学術論文・著書

2022

  1. Miyamoto D, Takeuchi K, Chihara K, Fujieda S, and Sada K. Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A. J Biol Chem. 2022 Apr;298(4):101804. Epub 2022 Mar 4.
  2. Morita N, Tanaka Y, Takeuchi K, Kitagawa Y, Sakuma R, Kide N, and Komatsu T. Macrophage phagocytosis by limiting the generation of intracellular double-stranded RNA. Front Microbiol. 2022 Feb 21;13:780534. 
  3. Chihara K, Chihara Y, Takeuchi K, and Sada K. Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation. Biochem J. 2022 Feb 17;479(4):503-523.
  4. Muramatsu I, Uwada J, Chihara K, Sada K, Wang MH., Yazawa T, Taniguchi T, Ishibashi T, and Masuoka T. Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum. J Neurochem. 2022 Feb;160(3):342-355.

2021

  1. Itoh K, Shigemi H, Chihara K, Sada K, Yamauchi T, and Iwasaki H. The suppressive effect of caspofungin on zymosan-induced cytokine and chemokine release in THP-1 cells: Possible involvement of the Syk pathway. Transl Res. 2021 Jan;227:53-63.

2019

  1. Uwada J, Yazawa T, Nakazawa H, Mikami D, Krug SM, Fromm M, Sada K, Muramatsu I, and Taniguchi T. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.
  2. Muramatsu I, Uwada J, Yoshiki H, Sada K, Lee KS, Yazawa T, Taniguchi T, Nishio M, Ishibashi T, and Masuoka T. Novel regulatory systems for acetylcholine release in rat striatum and anti-Alzheimer’s disease drugs. J Neurochem. 2019 Jun;149(5):605-623.

2018

  1. Odkhuu E, Komatsu T, Koide N, Naiki Y, Takeuchi K, Tanaka Y, Tsolmongyn B, Jambalganiin U, Morita N, Yoshida T, Gotoh B, and Yokochi T. Sendai virus C protein limits NO production in infected RAW264.7 macrophages. Innate Immun. 2018 Oct;24(7):430-438.
  2. Muramatsu I, Masuoka T, Uwada J, Yoshiki H, Yazama T, Lee KS, Sada K, Nishio M, Ishibashi T, and Taniguchi T. A new aspect of cholinergic transmission in the central nervous system. 2018 Apr 4. In: Akaike A, Shimohama S, Misu Y, editors. Nicotinic Acetylcholine Receptor Signaling in Neuroprotection [Internet]. Singapore: Springer; 2018. Chapter 3.
  3. Kowada K, Takeuchi K, Hirano E, Toho M, and Sada K. Development of a Multiplex Real-Time PCR Assay for Detection of Human Enteric Viruses Other Than Norovirus Using Samples Collected from Gastroenteritis Patients in Fukui Prefecture, Japan. J Med Virol. 2018 Jan;90(1):67-75.

2017

  1. Chihara K, Kato Y, Yoshiki H, Takeuchi K, Fujieda S, Sada K. Syk-dependent tyrosine phosphorylation of 3BP2 is required for FcRγ-mediated phagocytosis and chemokine expression in U937 cells. Sci Rep. 2017 Sep 13;7(1):11480.
  2. Takahashi N, Saeki T, Komatsuda A, Munemura C, Fukui T, Imai N, Homma N, Hatta T, Samejima KI, Fujimoto T, Omori H, Ito Y, Nishikawa Y, Kobayashi M, Morikawa Y, Fukushima S, Yokoi S, Mikami D, Kasuno K, Kimura H, Nemoto T, Nakamoto Y, Sada K, Sugai M, Naiki H, Yoshida H, Narita I, Saito Y, Iwano M.. Tubulointerstitial nephritis with IgM-positive plasma cells. J Am Soc Nephrol. 2017 Dec;28(12):3688-3698.
  3. Muramatsu I, Uwada J, Masuoka T, Yoshiki H, Sada K, Lee KS, Nishio M, Ishibashi T, and Taniguchi T. Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission. J Neurochem. 2017 Oct;143(1):76-86.
  4. Uwada J, Yazawa T, Islam MT, Khan MRI, Krug SM, Fromm M, Karaki SI, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, and Taniguchi T. Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK. Cell Signal. 2017 Jul;35:188-196.
  5. Honjoh C, Chihara K, Yoshiki H, Yamauchi S, Takeuchi K, Kato Y, Hida Y, Ishizuka T, and Sada K. Association of C-type lectin Mincle with FcεRIβγ subunits leads to functional activation of rat mast cells through Syk protein tyrosine kinase. Sci Rep. 2017 Apr 10;7:46064.

2016

  1. Yamauchi S, Takeuchi K, Chihara K, Honjoh C, Kato Y, Yoshiki H, Hotta H, and Sada K. STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α. Sci Rep. 2016 Dec 8;6:38336.
  2. Muramatsu I, Yoshiki H, Uwada J, Masuoka T, Sada K, Taniguchi T, Nishio M. Pharmacological evidence of specific acetylcholine transport in rat cerebral cortex and other brain regions. J Neurochem. 2016 Nov;139(4):566-575.

2015

  1. Yamauchi S, Takeuchi K, Chihara K, Sun X, Honjoh C, Yoshiki H, Hotta H, and Sada K. Hepatitis C virus particle assembly involves phosphorylation of NS5A by the c-Abl tyrosine kinase. J Biol Chem. 2015 Sep 4;290(36):21857-64.
  2. Muramatsu IYoshiki HSada K, Uwada J, Taniguchi T, Masuoka T, and Nishio M. Binding method for detection of muscarinic acetylcholine receptors in receptor’s natural environment. 2015. In: Myslivecek J and Jakubik J (eds.) Muscarinic Receptor: From Structure to Animal Models, Neuromethods 2015, 107:69-81 (chapter 4), Springer (Humana Press)
  3. Khan MR, Uwada J, Yazawa T, Islam MT, Krug SM, Fromm M, Karaki S, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, Anisuzzaman AS, and Taniguchi T. Activation of muscarinic cholinoceptor ameliorates tumor necrosis factor-α-induced barrier dysfunction in intestinal epithelial cells. FEBS Lett. 2015 Nov 30;589(23):3640-7.

2014

  1. Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H, Fujieda S, and Sada K. Dectin-1-mediated Signaling Leads to Characteristic Gene Expressions and Cytokine Secretion via Syk in Rat Mast Cells. J Biol Chem. 2014 Nov 7;289(45):31565-75.
  2. Chihara K, Kimura Y, Honjoh C, Yamauchi S, Takeuchi K, and Sada K. Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with Vav3 in chicken DT40 cells. Exp Cell Res. 2014 Mar 10;322(1):99-107.

2012

  1. Nakashima K, Takeuchi K, Chihara K, Horiguchi T, Sun X, Deng L, Shoji I, Hotta H, and Sada K. HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells. PLoS One. 2012;7(10):e46634.

2011

  1. Chihara K, Nakashima K, Takeuchi K, Sada K. Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-alpha in RBL-2H3 cells. Genes Cells. 2011 Dec;16(12):1133-45.
  2. Nakashima K, Takeuchi K, Chihara K, Hotta H, and Sada K. Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and -independent pathways. Microbiol Immunol. 2011 Nov;55(11):774-82.
  3. Ogi K, Nakashima K, Chihara K, Takeuchi K, Horiguchi T, Fujieda S, and Sada K. Enhancement of B cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism. Genes Cells. 2011 Sep;16(9):951-60.
  4. Horiguchi T, Ishiguro N, Chihara K, Ogi K, Nakashima K, Sada K, and Hori-Tamura N. Inhibitory effect of Acai (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation. J Agric Food Chem. 2011 May 25;59(10):5595-601.
  5. Kitagawa Y, Yamaguchi M, Zhou M, Komatsu T, Nishio M, Sugiyama T, Takeuchi K, Itoh M, and Gotoh B. A tryptophan-rich motif in the human parainfluenza virus type 2 v protein is critical for the blockade of toll-like receptor 7 (TLR7)- and TLR9-dependent signaling. J Virol. 2011 May;85(9):4606-11.

2010

  1. Kitagawa Y, Zhou M, Yamaguchi M, Komatsu T, Takeuchi K, Itoh M, and Gotoh B. Human metapneumovirus M2-2 protein inhibits viral transcription and replication. Microbes Infect. 2010 Feb;12(2):135-45.

2009

  1. Shukla U, Hatani T, Nakashima K, Ogi K, and Sada K. Tyrosine phosphorylation of 3BP2 regulates BCR-mediated activation of NFAT. J Biol Chem. 2009 Dec 4;284(49):33719-28.
  2. Qu X, Zhang Y, Li Y, Hu X, Xu Y, Xu L, Hou K, Sada K, and Liu Y. Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals. FEBS Lett. 2009 Jul 7;583(13):2255-62.
  3. Kasai D, Adachi T, Deng L, Nagano-Fujii M, Sada K, Ikeda M, Kato N, Ide YH, Shoji I, and Hotta H. HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters. J Hepatol. 2009 May;50(5):883-94.
  4. Zhang Y, Qu X, Hu X, Yang X, Hou K, Teng Y, Zhang J, Sada K, and Liu Y. Reversal of P-glycoprotein mediated multidrug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocartinoma cells. J Pathol. 2009 Jun;218(2):248-55.
  5. Xu L, Qu X, Zhang Y, Hu X, Yang X, Hou K, Teng Y, Zhang J, Sada K, and Liu Y. Oxaliplatin enhances TRAIL-induced apoptotis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts. FEBS Lett. 2009 Mar 4;583(5):943-8.

2008

  1. Takeuchi K, Komatsu T, Kitagawa Y, Sada K, and Gotoh B. Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA. J Virol. 2008 Oct;82(20):10102-10.
  2. Inubushi S, Nagano-Fujii M, Kitayama K, Tanaka M, An C, Yokozaki H, Yamamura H, Nuriya H, Kohara M, Sada K, and Hotta H. Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk. J Gen Virol. 2008 May;89(Pt 5):1231-1242.
  3. Hatani T and Sada K. Adaptor protein 3BP2 and cherubism. Curr Med Chem. 2008;15(6):549-54.

2007

  1. Komatsu TTakeuchi K, and Gotoh B. Bovine parainfluenza virus type 3 accessory
    proteins that suppress beta interferon production. Microbes Infect. 2007 Jul;9(8):954-62.

2006

  1. Yonashiro R, Ishido S, Kyo S, Fukuda T, Goto E, Matsuki Y, Ohmura-Hoshino M, Sada K, Hotta H, Yamamura H, Inatome R, Yanagi S. A novel mitochondria ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J. 2006 Aug 9;25(15):3618-26.
  2. Hotta H, Nihei K, Abe Y, Kato S, Jiang DP, Nagano-Fujii M, and Sada K. Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE. Microbiol Immunol. 2006;50(7):525-34.
  3. Nomura-Takigawa Y, Nagano-Fujii M, Deng L, Kitazawa S, Ishido S, Sada K, Hotta H. The nonstructural protein 4A of hepatitis C virus accumulates on mitochondria and induces apoptotic cell death through a mitochondria-mediated pathway. J Gen Virol. 2006 Jul;87(Pt 7):1935-1945.
  4. Deng L, Nagano-Fujii M, Tanaka M, Nomura-Takigawa Y, Ikeda M, Kato N, Sada K, and Hotta H. The NS3 protein of hepatitis C virus associates with the tumor suppressor p53 and inhibits its function in an NS3 sequence-dependent manner. J Gen Virol. 2006 Jun;87(Pt 6):1703-1713.
  5. Otaki M, Sada K, Kadoya H, Nagano-Fujii M, Hotta H. Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference. Antiviral Res. 2006 Jul;70(3):105-11.

和文総説等

2018

  1. 千原一泰本定千知木村幸弘竹内健司,藤枝重治,石塚 全,定 清直C型レクチンによるマスト細胞の活性化メカニズム. 臨床免疫・アレルギー科 2018, 69(3):271-276.

2017

  1. 本定 千知, 千原 一泰, 吉木 はつみ, 山内 翔太, 竹内 健司, 加藤 雄士, 飛田 征男, 石塚 全, 定 清直.マスト細胞におけるC型レクチンMincleの機能解析. 日本呼吸器学会誌 2017. 6. 増刊. 234-234.

2014

  1. 本定千知千原一泰木村幸弘竹内健司定 清直.関最新節リウマチ学寛解・治癒を目指した研究と最新治療― Syk阻害薬. 日本臨牀増刊号「最新関節リウマチ学寛解・治癒を目指した研究と最新治療」2014, 521-524.

2013

  1. Chihara K, Kimura Y, Honjo C, Takeuchi K, and Sada K. Syk inhibitors. Nihon Rinsho Meneki Gakkai Kaishi. 2013;36(4):197-202. English, Japanese.
  2. Kimura Y, Chihara K, Takeuchi K, and Sada K. Syk inhibitors. Nihon Rinsho. 2013 Jul;71(7):1248-52. Japanese.

2012

  1. 千原一泰中島謙治竹内健司定 清直Spleen tyrosine kinase (Syk)の生理的役割とその阻害薬の作用. リウマチ科 2012, 47(6):694-699.
  2. 定 清直Syk阻害薬. 特集 リウマチ治療薬の新展開. 医薬ジャーナル 2012, 48(6):1531-1534.
  3. 定 清直Syk阻害薬チロシンキナーゼSykの基礎と臨床-.炎症疾患におけるキナーゼ阻害薬の進歩. 医学のあゆみ 2012, 240(7):567-570.
  4. 中島謙治千原一泰竹内健司定 清直.次世代低分子化合物:Syk阻害薬.特集 関節リウマチの最新情報寛解を目指した診断と治療の新展開-. 最新医学 2012, 67(2):101-106.

2010

  1. 千原一泰定 清直.関節リウマチ治療におけるSyk阻害薬の可能性を探る.特集 次世代の低分子量化合物は生物学的製剤を超えることができるか. 分子リウマチ治療 2010, 3(4):186-189.
  2. 定 清直C型肝炎ウイルスの病原性発現機構. 小児感染免疫 2010, 22(1): 35-41.

2009

  1. 羽溪朋子定 清直Syk阻害剤. 特集 低分子抗炎症薬. 炎症と免疫 2009, 17(5):530-537.

 

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